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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe.

We cloned the myo3+ gene of Schizosaccharomyces pombe which encodes a type-II myosin heavy chain. myo3 null cells showed a defect in cytokinesis under certain conditions. Overproduction of Myo3 also showed a defect in cytokinesis. Double mutant analysis indicated that Myo3 genetically interacts with Cdc8 tropomyosin and actin. Myo3 may be implicated in cytokinesis and stabilization of F-actin cables. Moreover, the function of Myo2 can be replaced by overexpressed Myo3. We observed a modest synthetic interaction between Myo2 and Myo3. Thus, Myo2 and Myo3 seem to cooperate in the formation of the F-actin ring in S. pombe.[1]

References

  1. Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe. Motegi, F., Nakano, K., Kitayama, C., Yamamoto, M., Mabuchi, I. FEBS Lett. (1997) [Pubmed]
 
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