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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Blood-borne seeding by hematopoietic and endothelial precursors from the allantois.

Until now the allantois has not been considered as a hematopoietic organ. Here we report experimental evidence demonstrating the in situ emergence of both hematopoietic and endothelial precursors in the avian allantoic bud. When the prevascularized allantoic bud from a quail embryo was grafted in the coelom of a chicken host, hematopoietic and endothelial cells later were found in the bone marrow of the host. Because the graft was located at a distance from the limb bud, these cells could reach the bone marrow only by the circulatory pathway. This blood-borne seeding may be accomplished by distinct hematopoietic and endothelial precursors, or by hemangioblasts, the postulated common precursors of these two lineages; we consider the latter interpretation more likely. We also show by reverse transcription-PCR that the allantois region expresses very early the GATA genes involved in hematopoiesis and some beta-globin chain genes.[1]


  1. Blood-borne seeding by hematopoietic and endothelial precursors from the allantois. Caprioli, A., Jaffredo, T., Gautier, R., Dubourg, C., Dieterlen-Lièvre, F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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