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MeSH Review


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Disease relevance of Hematopoiesis


Psychiatry related information on Hematopoiesis


High impact information on Hematopoiesis

  • Cdk6-null mice are viable and develop normally although hematopoiesis is slightly impaired [9].
  • Ang-1, the ligand for Tie2, enhanced the ability of HSCs to become quiescent and also induced their adhesion to bone, protecting them from stresses that suppress hematopoiesis [10].
  • The similar autosomal recessive disease of dogs, canine cyclic hematopoiesis, is not caused by mutations in ELA2 (data not shown) [11].
  • Both RUNX1 and CBFbeta are essential for hematopoiesis [12].
  • To investigate this issue, we rescued hematopoiesis of Cbfb(-/-) mice by introducing Cbfb using the Gata1 promoter [12].

Chemical compound and disease context of Hematopoiesis


Biological context of Hematopoiesis


Anatomical context of Hematopoiesis


Associations of Hematopoiesis with chemical compounds

  • The effect of lithium on murine hematopoiesis in a liquid culture system [25].
  • The products of androgen metabolism may also play active regulatory roles in hematopoiesis and in the regulation of certain hepatic enzymes [26].
  • These studies demonstrate a reproducible way to immortalize lymphohematopoietic progenitors and implicate specific roles for retinoic acid receptors at two distinct stages of hematopoiesis [27].
  • We have investigated the function of TIE2/TEK receptor tyrosine kinase in the development of definitive hematopoiesis [28].
  • The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis [29].

Gene context of Hematopoiesis


Analytical, diagnostic and therapeutic context of Hematopoiesis


  1. Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes. Vadhan-Raj, S., Keating, M., LeMaistre, A., Hittelman, W.N., McCredie, K., Trujillo, J.M., Broxmeyer, H.E., Henney, C., Gutterman, J.U. N. Engl. J. Med. (1987) [Pubmed]
  2. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.P., Gabriele, L., Waring, J.F., Bachmann, M.F., Zinkernagel, R.M., Morse, H.C., Ozato, K., Horak, I. Cell (1996) [Pubmed]
  3. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Castilla, L.H., Wijmenga, C., Wang, Q., Stacy, T., Speck, N.A., Eckhaus, M., Marín-Padilla, M., Collins, F.S., Wynshaw-Boris, A., Liu, P.P. Cell (1996) [Pubmed]
  4. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T.M., Amakawa, R., Kishihara, K., Wakeham, A. Cell (1993) [Pubmed]
  5. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., Köhler, G. Nature (1994) [Pubmed]
  6. Molecular targets of lithium action. Phiel, C.J., Klein, P.S. Annu. Rev. Pharmacol. Toxicol. (2001) [Pubmed]
  7. Immunohistochemical detection of cells positive for colony-stimulating factor 1 in lymph nodes from reactive lymphadenitis, and Hodgkin's disease. Moreau, A., Praloran, V., Berrada, L., Coupey, L., Gaillard, F. Leukemia (1992) [Pubmed]
  8. Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection. Yaegashi, N. Tohoku J. Exp. Med. (2000) [Pubmed]
  9. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Malumbres, M., Sotillo, R., Santamaría, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., Barbacid, M. Cell (2004) [Pubmed]
  10. "Tie-ing" down the hematopoietic niche. Moore, K.A., Lemischka, I.R. Cell (2004) [Pubmed]
  11. Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Benson, K.F., Li, F.Q., Person, R.E., Albani, D., Duan, Z., Wechsler, J., Meade-White, K., Williams, K., Acland, G.M., Niemeyer, G., Lothrop, C.D., Horwitz, M. Nat. Genet. (2003) [Pubmed]
  12. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Yoshida, C.A., Furuichi, T., Fujita, T., Fukuyama, R., Kanatani, N., Kobayashi, S., Satake, M., Takada, K., Komori, T. Nat. Genet. (2002) [Pubmed]
  13. Differentiation of mouse erythroleukemia cells enhanced by alternatively spliced c-myb mRNA. Weber, B.L., Westin, E.H., Clarke, M.F. Science (1990) [Pubmed]
  14. Sustained response to recombinant human erythropoietin and intermittent all-trans retinoic acid in patients with myelodysplastic syndromes. Stasi, R., Brunetti, M., Terzoli, E., Amadori, S. Blood (2002) [Pubmed]
  15. Effect of human immunodeficiency virus-1 envelope glycoprotein on in vitro hematopoiesis of umbilical cord blood. Sugiura, K., Oyaizu, N., Pahwa, R., Kalyanaraman, V.S., Pahwa, S. Blood (1992) [Pubmed]
  16. Characteristic abnormality of deoxyribonucleoside triphosphate metabolism in megaloblastic anemia. Iwata, N., Omine, M., Yamauchi, H., Maekawa, T. Blood (1982) [Pubmed]
  17. Stimulation of hematopoiesis by amifostine in patients with myelodysplastic syndrome. List, A.F., Brasfield, F., Heaton, R., Glinsmann-Gibson, B., Crook, L., Taetle, R., Capizzi, R. Blood (1997) [Pubmed]
  18. Self-renewal and differentiation of normal avian erythroid progenitor cells: regulatory roles of the TGF alpha/c-ErbB and SCF/c-kit receptors. Hayman, M.J., Meyer, S., Martin, F., Steinlein, P., Beug, H. Cell (1993) [Pubmed]
  19. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Okuda, T., van Deursen, J., Hiebert, S.W., Grosveld, G., Downing, J.R. Cell (1996) [Pubmed]
  20. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Shultz, L.D., Schweitzer, P.A., Rajan, T.V., Yi, T., Ihle, J.N., Matthews, R.J., Thomas, M.L., Beier, D.R. Cell (1993) [Pubmed]
  21. Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Arroyo, A.G., Yang, J.T., Rayburn, H., Hynes, R.O. Cell (1996) [Pubmed]
  22. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Miller, J., Horner, A., Stacy, T., Lowrey, C., Lian, J.B., Stein, G., Nuckolls, G.H., Speck, N.A. Nat. Genet. (2002) [Pubmed]
  23. A role for hematopoietic stem cells in promoting angiogenesis. Takakura, N., Watanabe, T., Suenobu, S., Yamada, Y., Noda, T., Ito, Y., Satake, M., Suda, T. Cell (2000) [Pubmed]
  24. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Wang, Q., Stacy, T., Miller, J.D., Lewis, A.F., Gu, T.L., Huang, X., Bushweller, J.H., Bories, J.C., Alt, F.W., Ryan, G., Liu, P.P., Wynshaw-Boris, A., Binder, M., Marín-Padilla, M., Sharpe, A.H., Speck, N.A. Cell (1996) [Pubmed]
  25. The effect of lithium on murine hematopoiesis in a liquid culture system. Levitt, L.J., Quesenberry, P.J. N. Engl. J. Med. (1980) [Pubmed]
  26. Biological actions of androgens. Mooradian, A.D., Morley, J.E., Korenman, S.G. Endocr. Rev. (1987) [Pubmed]
  27. Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development. Tsai, S., Bartelmez, S., Sitnicka, E., Collins, S. Genes Dev. (1994) [Pubmed]
  28. Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Takakura, N., Huang, X.L., Naruse, T., Hamaguchi, I., Dumont, D.J., Yancopoulos, G.D., Suda, T. Immunity (1998) [Pubmed]
  29. The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Emambokus, N.R., Frampton, J. Immunity (2003) [Pubmed]
  30. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Neubauer, H., Cumano, A., Müller, M., Wu, H., Huffstadt, U., Pfeffer, K. Cell (1998) [Pubmed]
  31. Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Urness, L.D., Sorensen, L.K., Li, D.Y. Nat. Genet. (2000) [Pubmed]
  32. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Zou, Y.R., Kottmann, A.H., Kuroda, M., Taniuchi, I., Littman, D.R. Nature (1998) [Pubmed]
  33. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Gerber, H.P., Malik, A.K., Solar, G.P., Sherman, D., Liang, X.H., Meng, G., Hong, K., Marsters, J.C., Ferrara, N. Nature (2002) [Pubmed]
  34. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Tsai, F.Y., Keller, G., Kuo, F.C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F.W., Orkin, S.H. Nature (1994) [Pubmed]
  35. A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro. Gewirtz, A.M., Calabretta, B. Science (1988) [Pubmed]
  36. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Wang, X., Blagden, C., Fan, J., Nowak, S.J., Taniuchi, I., Littman, D.R., Burden, S.J. Genes Dev. (2005) [Pubmed]
  37. Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus. Hawley, R.G., Fong, A.Z., Burns, B.F., Hawley, T.S. J. Exp. Med. (1992) [Pubmed]
  38. Effects of recombinant human granulocyte-macrophage colony-stimulating factor on myelosuppression induced by multiple cycles of high-dose chemotherapy in patients with advanced breast cancer. Hoekman, K., Wagstaff, J., van Groeningen, C.J., Vermorken, J.B., Boven, E., Pinedo, H.M. J. Natl. Cancer Inst. (1991) [Pubmed]
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