Stunning effects after a diagnostic dose of iodine-131.
AIM: To understand stunning effects of a diagnostic dose of iodine-131 (I-131). METHODS: Four hundred and sixty-eight patients (101 males, 367 females, ages: 6-75 years with well differentiated thyroid cancer, following total or nearly total thyroidectomy, were studied. One hundred and eleven MBq (3 mCi) diagnostic (Dx) doses of I-131 whole body scan ( WBS) were obtained after withholding thyroxine after 6 weeks and triiodothyronine for 2 weeks. One week to one month later, 3.7-7.4 GBq (100-200 mCi) I-131 was given to them, then a therapeutic (Tx) dose of I-131 WBS was performed. The serum thyroid simulating hormone level was usually above muIU/ml. RESULTS: Of the 468 patients, 344 (73.5%) had scintigraphic patterns of apparently decrease uptake in 240 thyroid remnants and 104 metastatic lesions on the Tx dose of I-131 WBS compared to Dx dose of I-131 WBS. Stunning phenomenon occurred in 50 cases, including 42 thyroid remnants and 18 metastatic lesions. CONCLUSION: Dx dose of I-131 may influence the uptake of a subsequently administered Tx dose of I-131.[1]References
- Stunning effects after a diagnostic dose of iodine-131. Kao, C.H., Yen, T.C. Nuklearmedizin. (1998) [Pubmed]
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