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MeSH Review


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Disease relevance of Thyroidectomy


High impact information on Thyroidectomy

  • Total thyroidectomy is best avoided in most cases, considering the price of hypoparathyroidism and the lack of significant improvement in survival compared with lesser ablative techniques [6].
  • The patients in group 1 were randomly assigned to treatment with methimazole for 18 months or subtotal thyroidectomy, and those in group 2 to either of these two treatments or to iodine-131 therapy [7].
  • We assessed thyroid function for 12 months after subtotal thyroidectomy in 100 tyrotoxic patients treated with propranolol alone before and immediately after operation [8].
  • Three standard management plans were considered: immediate subtotal thyroidectomy; a six month trial of thyroid suppression with L-thyroxine, with non-suppressible lesions being removed surgically; and aspiration cytology followed by surgery or thyroid suppression based on the cytologic examination [9].
  • Nevertheless, serum TG determinations are useful for assessing the presence and possibly the extent of residual or recurrent nonmedullary thyroid cancer in patients who have undergone total thyroidectomy [10].

Chemical compound and disease context of Thyroidectomy


Biological context of Thyroidectomy


Anatomical context of Thyroidectomy


Associations of Thyroidectomy with chemical compounds


Gene context of Thyroidectomy

  • A significant correlation between numbers of Fos-like IR cells in the pPVN and plasma TSH concentration following thyroidectomy was also observed, suggesting that plasma levels of TSH correlate directly with the number of activated TRH-containing neurons located in the pPVN [30].
  • To achieve these goals, we determined the frequency of occult PTC among patients operated for MTC (n = 82) or undergoing total thyroidectomy mainly for goiter and/or nodules (n = 7313) between 1994-2001 [31].
  • Several weeks after thyroidectomy (T), female rats stopped growing, and their pituitary GH content had decreased to less than 2--3% of the values found for age-matched controls (C) [32].
  • Initial treatment of MTC is total thyroidectomy, regardless of its genetic type or putative sporadic nature, because surgery offers the only chance for a cure [33].
  • Quantitative measurement of thyroglobulin mRNA in peripheral blood of patients after total thyroidectomy [34].

Analytical, diagnostic and therapeutic context of Thyroidectomy


  1. Thyroidectomy for amiodarone-induced thyrotoxicosis. Farwell, A.P., Abend, S.L., Huang, S.K., Patwardhan, N.A., Braverman, L.E. JAMA (1990) [Pubmed]
  2. Thyroid hormone modulation of the hypothalamic growth hormone (GH)-releasing factor-pituitary GH axis in the rat. Miki, N., Ono, M., Hizuka, N., Aoki, T., Demura, H. J. Clin. Invest. (1992) [Pubmed]
  3. Short-term triiodothyronine in prevention of temporary hypothyroidism after subtotal thyroidectomy for Graves' disease. Wilkin, T.J., Gunn, A., Isles, T.E., Crooks, J., Beck, J.S. Lancet (1979) [Pubmed]
  4. Inhibition of the growth of Morris hepatoma No. 44 in rats after induction of hypothyroidism: evidence that Morris hepatomas are thyroid dependent. Mishkin, S., Morris, H.P., Yalovsky, M.A., Murthy, P.V. Gastroenterology (1979) [Pubmed]
  5. Thyroid cancer: a lethal endocrine neoplasm. Robbins, J., Merino, M.J., Boice, J.D., Ron, E., Ain, K.B., Alexander, H.R., Norton, J.A., Reynolds, J. Ann. Intern. Med. (1991) [Pubmed]
  6. Thyroid cancer: some basic considerations. Wanebo, H.J., Andrews, W., Kaiser, D.L. CA: a cancer journal for clinicians. (1983) [Pubmed]
  7. Occurrence of ophthalmopathy after treatment for Graves' hyperthyroidism. The Thyroid Study Group. Tallstedt, L., Lundell, G., Tørring, O., Wallin, G., Ljunggren, J.G., Blomgren, H., Taube, A. N. Engl. J. Med. (1992) [Pubmed]
  8. Thyroid function after surgical treatment of thyrotoxicosis. A report of 100 cases treated with propranolol before operation. Toft, A.D., Irvine, W.J., Sinclair, I., McIntosh, D., Seth, J., Cameron, E.H. N. Engl. J. Med. (1978) [Pubmed]
  9. The cold thyroid nodule: an analysis of diagnostic and therapeutic options. Molitch, M.E., Beck, J.R., Dreisman, M., Gottlieb, J.E., Pauker, S.G. Endocr. Rev. (1984) [Pubmed]
  10. Thyroglobulin in benign and malignant thyroid disease. Gerfo, P.L., Colacchio, T., Colacchio, D., Feind, C. JAMA (1979) [Pubmed]
  11. Inhibition of experimentally induced cirrhosis in rats by hypothyroidism. Oren, R., Dotan, I., Papa, M., Marravi, Y., Aeed, H., Barg, J., Zeidel, L., Bruck, R., Halpern, Z. Hepatology (1996) [Pubmed]
  12. Propranolol in the treatment of thyrotoxicosis by subtotal thyroidectomy. Toft, A.D., Irvine, W.J., McIntosh, D., MacLeod, D.A., Seth, J., Cameron, E.H., Lidgard, G.P. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  13. Adrenergic regulation of beta-endorphin secretion from anterior pituitary in conscious rats: effects of thyroid state. Ishac, E.J., Eskay, R., Hirata, F., Axelrod, J., Kunos, G. Endocrinology (1987) [Pubmed]
  14. Serial glomerular and tubular dynamics in thyroidectomized rats with remnant kidneys. Falk, S.A., Buric, V., Hammond, W.S., Conger, J.D. Am. J. Kidney Dis. (1991) [Pubmed]
  15. Effect of hypothyroidism on methylmalonate excretion and hepatic vitamin B-12 levels in rats. Stokstad, E.L., Nair, C.P. J. Nutr. (1988) [Pubmed]
  16. Total thyroidectomy does not enhance disease control or survival even in high-risk patients with differentiated thyroid cancer. Wanebo, H., Coburn, M., Teates, D., Cole, B. Ann. Surg. (1998) [Pubmed]
  17. Various penetrance of familial medullary thyroid carcinoma in patients with RET protooncogene codon 790/791 germline mutations. Fitze, G., Schierz, M., Bredow, J., Saeger, H.D., Roesner, D., Schackert, H.K. Ann. Surg. (2002) [Pubmed]
  18. Reduced bone mineral content in totally thyroidectomized patients: possible effect of calcitonin deficiency. McDermott, M.T., Kidd, G.S., Blue, P., Ghaed, V., Hofeldt, F.D. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  19. Developmental regulation of hepatic and renal gluconeogenic enzymes by thyroid hormones in fetal sheep during late gestation. Forhead, A.J., Poore, K.R., Mapstone, J., Fowden, A.L. J. Physiol. (Lond.) (2003) [Pubmed]
  20. Effects of thyroid and ovaries on prolactin binding activity in rat liver. Gelato, M., Marshall, S., Boudreau, M., Bruni, J., Campbell, G.A., Meites, J. Endocrinology (1975) [Pubmed]
  21. Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Koller, K.J., Wolff, R.S., Warden, M.K., Zoeller, R.T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  22. Total thyroidectomy. The preferred option for multinodular goiter. Reeve, T.S., Delbridge, L., Cohen, A., Crummer, P. Ann. Surg. (1987) [Pubmed]
  23. Parathyroid autotransplantation during thyroidectomy. Results of long-term follow-up. Olson, J.A., DeBenedetti, M.K., Baumann, D.S., Wells, S.A. Ann. Surg. (1996) [Pubmed]
  24. Role of triiodothyronine in down-regulation and recovery of lymphocyte beta-adrenoceptors in thyroidectomized patients. Basso, A., Piantanelli, L., Rossolini, G., Piloni, S., Vitali, C., Masera, N. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  25. The effect of bilateral lesions of the ventral noradrenergic bundle on endocrine-induced changes of tyrosine hydroxylase in the rat median eminence. Kizer, J.S., Muth, E., Jacobowitz, D.M. Endocrinology (1976) [Pubmed]
  26. Effects of thyroidectomy and triiodothyronine administration on rat liver alcohol dehydrogenase. Mezey, E., Potter, J.J. Gastroenterology (1981) [Pubmed]
  27. Serum thyroglobulin in thyroid cancer. Black, E.G., Cassoni, A., Gimlette, T.M., Harmer, C.L., Maisey, M.N., Oates, G.D., Hoffenberg, R. Lancet (1981) [Pubmed]
  28. Effects of amiodarone on thyroid function. Harjai, K.J., Licata, A.A. Ann. Intern. Med. (1997) [Pubmed]
  29. Selective hormonal control of myo-inositol biosynthesis in reproductive organs and liver of the male rat. Hasegawa, R., Eisenberg, F. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  30. Thyroidectomy induces Fos-like immunoreactivity within thyrotropin-releasing hormone-expressing neurons located in the paraventricular nucleus of the adult rat hypothalamus. Koibuchi, N., Gibbs, R.B., Suzuki, M., Pfaff, D.W. Endocrinology (1991) [Pubmed]
  31. Thyroid carcinomas involving follicular and parafollicular C cells: seventeen cases with characterization of RET oncogenic activation. Vantyghem, M.C., Pigny, P., Leteurtre, E., Leclerc, L., Bauters, C., Douillard, C., D'Herbomez, M., Carnaille, B., Proye, C., Wemeau, J.L., Lecomte-Houcke, M. Thyroid (2004) [Pubmed]
  32. Effects of thyroid hormones on liver binding sites for human growth hormone, as studied in the rat. Duran-Garcia, S., Gomez-Nieto, J., Fouchereau-Peron, M., Padron, V.F., Obregon, M.J., Morreale de Escobar, G., Escobar del Rey, F. Clin. Endocrinol. (Oxf) (1979) [Pubmed]
  33. Diagnosis and management of medullary thyroid carcinoma. Massoll, N., Mazzaferri, E.L. Clin. Lab. Med. (2004) [Pubmed]
  34. Quantitative measurement of thyroglobulin mRNA in peripheral blood of patients after total thyroidectomy. Takano, T., Miyauchi, A., Yoshida, H., Hasegawa, Y., Kuma, K., Amino, N. Br. J. Cancer (2001) [Pubmed]
  35. Interacting role of thyroxine and growth hormone in the hepatic synthesis of alpha 2u-globulin and its messenger RNA. Chatterjee, B., Demyan, W.F., Roy, A.K. J. Biol. Chem. (1983) [Pubmed]
  36. Concomitant Graves' disease and primary hyperparathyroidism. Influence of hyperthyroidism on serum calcium and parathyroid hormone. Arem, R., Lim-Abrahan, M.A., Mallette, L.E. Am. J. Med. (1986) [Pubmed]
  37. Hepatic messenger ribonucleic acid activity profile of rats subjected to alterations in thyroidal and adrenocortical states: evidence for significant interaction. Beyer, H.S., Carr, F.E., Mariash, C.N., Oppenheimer, J.H. Endocrinology (1985) [Pubmed]
  38. False-positive findings on (131)I whole-body scans because of posttraumatic superficial scabs. Regalbuto, C., Buscema, M., Arena, S., Vigneri, R., Squatrito, S., Pezzino, V. J. Nucl. Med. (2002) [Pubmed]
  39. Continuous infusion of growth hormone feminizes hepatic steroid metabolism in the rat. Mode, A., Norstedt, G., Simic, B., Eneroth, P., Gustafsson, J.A. Endocrinology (1981) [Pubmed]
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