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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family.

We have isolated cDNA encoding a novel member (207 amino acids) of the FGF family from the rat heart by homology-based polymerase chain reaction. As this protein is the 16th documented member of the FGF family, we tentatively term it FGF-16. Among FGF family members, FGF-16 is most similar (73% amino acid identity) to FGF-9. We have also determined the structure of human FGF-16 with high amino acid sequence identity (98.6%) to rat FGF-16. Although the predicted FGF-16 amino acid sequence lacks a typical signal sequence, recombinant rat FGF-16 was efficiently secreted by Sf9 insect cells infected with recombinant baculovirus containing the cDNA. FGF-16 mRNA was predominantly expressed in the rat heart among the adult major tissues examined. The expression profile of FGF-16 mRNA was quite different from those of other members of the FGF family. In rat embryos, FGF-16 mRNA was predominantly expressed in the brown adipose tissue. However, the expression decreased greatly after birth. These results indicate that FGF-16 in embryos might play a role in development of the brown adipose tissue.[1]


  1. Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. Miyake, A., Konishi, M., Martin, F.H., Hernday, N.A., Ozaki, K., Yamamoto, S., Mikami, T., Arakawa, T., Itoh, N. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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