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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Analysis of the retinoic acid receptor alpha gene as a candidate for the pulmonary adenoma resistance 1 gene.

The retinoic acid receptor alpha (Rara) gene, which maps in the same region as the pulmonary adenoma resistance (Par1) locus on mouse chromosome 11 (Manenti G et al., Nature Genet 12:455-457, 1996), was tested as a candidate gene for Par1. We report here the analysis of loss of heterozygosity, nucleotide sequence comparison, gene expression, and biochemical activity of the Rara gene from the Mus spretus(Par1/+) and A/J (Par1/-) mouse strains. The two Rara alleles were distinguished by two amino-acid variations but had similar biochemical activity and expression levels, leading to the exclusion of Rara as a candidate Par1 gene.[1]

References

  1. Analysis of the retinoic acid receptor alpha gene as a candidate for the pulmonary adenoma resistance 1 gene. Gariboldi, M., Vivat, V., De Gregorio, L., Manenti, G., Chiariello, E., Falvella, F.S., Pierotti, M.A., Dragani, T.A. Mol. Carcinog. (1998) [Pubmed]
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