The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells.

CD40- CD40-ligand ( CD154) interactions play a critical role in immune activation. Using replication defective adenovirus encoding mouse CD154 (Ad- CD154), we modified human chronic lymphocytic leukemia B cells to express a functional ligand for CD40. This not only induces expression of immune accessory molecules on the infected cell, but also allows it to trans-activate noninfected bystander leukemia B cells. Also, factors that impair the antigen-presenting capacity of leukemia B cells are downmodulated. Ad- CD154- infected leukemia cells are highly effective stimulators in mixed lymphocyte reactions and can induce generation of cytotoxic T lymphocytes specific for autologous nonmodified leukemia cells. As such, Ad- CD154 can induce a host antileukemia response that may have therapeutic potential.[1]

References

  1. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. Kato, K., Cantwell, M.J., Sharma, S., Kipps, T.J. J. Clin. Invest. (1998) [Pubmed]
 
WikiGenes - Universities