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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Rheumatoid arthritis associated with renal amyloidosis and crescentic glomerulonephritis.

A 43-year-old woman with rheumatoid arthritis ( RA), renal amyloidosis and crescentic glomerulonephritis had severe abdominal pain, melena and progressive renal failure. Autopsy findings revealed vasculitis of small and middle size of vessels and there was a deposition of amyloid in the small intestines. Although there were no findings of vasculitis in the kidney, amyloid deposition was noticed and 70-80% of glomeruli showed a crescentic formation. No immunological abnormality was found in glomeruli. Although the immunological mechanisms of crescentic glomerulonephritis were not necessarily eliminated, amyloid deposition may play a role in crescent formation.[1]


  1. Rheumatoid arthritis associated with renal amyloidosis and crescentic glomerulonephritis. Murakami, H., Ura, N., Nagao, K., Tsuchihashi, K., Nakata, T., Agata, J., Satoh, M., Shimamoto, K. Intern. Med. (1998) [Pubmed]
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