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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

A comparison of 2 patient populations using fractal analysis.

This study was undertaken to demonstrate that the fractal dimensions calculated using digitized non-standardized, clinical radiographs of mandibular alveolar bone from a population of patients diagnosed with periodontitis are statistically different from fractal dimensions calculated from another population diagnosed as having gingivitis or healthy gingiva. The fractal dimension was calculated using a public domain fractal analysis program distributed by the National Institutes of Health (NIH). Fractal dimensions were calculated from digitized clinical radiographs for 29 patients diagnosed with healthy gingiva and/or gingivitis and 32 patients diagnosed with periodontitis and compared. To estimate the reproducibility of the technique, we recalculated the fractal dimension from images of the gingivitis patients 3 months after the original calculations and compared them to the originals. A 2 sample, 2-tailed Student t test showed the gingivitis data group to be different from the periodontitis data group (P = 0.0012). The original gingivitis and repeat gingivitis groups fractal dimension calculation were the same and analysis showed the two data sets were not significantly different (P = 0.99). We found that: 1) fractal dimensions could be used to distinguish between gingivitis and periodontitis patient groups; 2) fractal dimensions could be calculated from non-standardized clinical radiographs; and 3) fractal dimensions for gingivitis patients were reproducible over a 3-month period.[1]

References

  1. A comparison of 2 patient populations using fractal analysis. Shrout, M.K., Roberson, B., Potter, B.J., Mailhot, J.M., Hildebolt, C.F. J. Periodontol. (1998) [Pubmed]
 
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