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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Gingivitis


Psychiatry related information on Gingivitis


High impact information on Gingivitis


Chemical compound and disease context of Gingivitis


Biological context of Gingivitis


Anatomical context of Gingivitis


Gene context of Gingivitis

  • The levels of t-PA and PAI-2 were significantly higher in CsA GO- sites compared with those of CsA-H, gingivitis and healthy sites (p<0.05) [24].
  • Our findings suggest that in vivo activated MMP-8 in GCF derived from triggered PMNs and/or cytokine-induced periodontal fibroblasts may reflect periodontal tissue and alveolar bone destruction seen in the early stages of gingivitis/periodontitis associated with Down's syndrome [25].
  • CONCLUSIONS: VEGF may be a factor in initiation and progression of gingivitis to periodontitis, possibly by promoting expansion of the vascular network coincident to progression of the inflammation [26].
  • MATERIAL AND METHODS: Immunohistochemical analysis was performed on cryostat sections of gingival tissues from 19 patients with periodontitis and eight patients with gingivitis using antibodies to CD1a, b, c, d, Valpha24(+) invariant NKT cells, CD83, CD3 and CD19 [27].
  • Intracellular adhesion molecule-1 (ICAM-1) was higher in periodontitis than in gingivitis and interleukin-8 mRNA was higher in lesions with a pronounced neutrophil infiltrate [28].

Analytical, diagnostic and therapeutic context of Gingivitis

  • The concentration of alpha 2-macroglobulin (alpha 2-M) in human gingival sulci has been investigated in two studies: first, in gingival washings during a 21-day period of experimental gingivitis in eight human volunteers and, second, in crevicular fluid collected with filter paper strips before and after initial periodontal therapy in 11 patients [9].
  • The aim of this cohort study was to determine whether periodontitis and gingivitis are associated with impaired salivary antioxidant status and increased oxidative injury [29].
  • The efficacy of triclosan-containing toothpaste and mouthrinse to reduce both plaque and gingivitis in long-term clinical trials has been well documented [30].
  • Under conditions of a clinical double-blind study, the influence of an amine/stannous fluoride rinse on gingivitis, plaque accumulation and the composition of the supragingival plaque was tested over a period of 7 months [31].
  • Caries and gingivitis prevention may benefit from chemotherapeutic plaque control, therefore we compared in a cross-over study with 5 subjects the anti-acidogenic effects of a single use of AmF-SnF2 mouthrinse solutions (Meridol with and without 5% alcohol) with baseline and with the effects of a placebo and a chlorhexidine mouthrinse (CHX) [32].


  1. Influence of heparin(s) on the interleukin-1-beta-induced expression of collagenase, stromelysin-1, and tissue inhibitor of metalloproteinase-1 in human gingival fibroblasts. Gogly, B., Hornebeck, W., Groult, N., Godeau, G., Pellat, B. Biochem. Pharmacol. (1998) [Pubmed]
  2. Effect of toothbrushing with different concentrations of chlorhexidine on the development of dental plaque and gingivitis. Bay, L.M. J. Dent. Res. (1978) [Pubmed]
  3. Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency. Krauser, J.A., Potempa, J., Travis, J., Powers, J.C. Biol. Chem. (2002) [Pubmed]
  4. The efficacy of topical cyclosporin in the management of desquamative gingivitis due to lichen planus. Porter, S.R., Scully, C., Eveson, J.W. Br. J. Dermatol. (1993) [Pubmed]
  5. A case of Behçet's disease aggravated by gingival infection with methicillin-resistant Staphylococcus aureus. Suga, Y., Tsuboi, R., Kobayashi, S., Ogawa, H. Br. J. Dermatol. (1995) [Pubmed]
  6. Effects of chlorhexidine spray on plaque and gingival health in institutionalized persons with mental retardation. Burtner, A.P., Low, D.W., McNeal, D.R., Hassell, T.M., Smith, R.G. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. (1991) [Pubmed]
  7. Qualitative and quantitative analysis of tocopherols in toothpastes and gingival tissue employing HPLC NMR and HPLC MS coupling. Lienau, A., Glaser, T., Krucker, M., Zeeb, D., Ley, F., Curro, F., Albert, K. Anal. Chem. (2002) [Pubmed]
  8. Comparative bacteriology of juvenile periodontitis. Moore, W.E., Holdeman, L.V., Cato, E.P., Smibert, R.M., Burmeister, J.A., Palcanis, K.G., Ranney, R.R. Infect. Immun. (1985) [Pubmed]
  9. Alpha 2-macroglobulin in sulci from healthy and inflamed human gingivae. Condacci, I., Cimasoni, G., Ahmad-Zadeh, C. Infect. Immun. (1982) [Pubmed]
  10. Edema in oral mucosa after LPS or cytokine exposure. Bletsa, A., Nedrebø, T., Heyeraas, K.J., Berggreen, E. J. Dent. Res. (2006) [Pubmed]
  11. Cell-surface proteoglycan expression by lymphocytes from peripheral blood and gingiva in health and periodontal disease. Manakil, J.F., Sugerman, P.B., Li, H., Seymour, G.J., Bartold, P.M. J. Dent. Res. (2001) [Pubmed]
  12. Inhibition of plaque formation and gingivitis in beagle dogs by topical use of a degradable controlled-release system containing chlorhexidine. Kozlovsky, A., Sintov, A., Zubery, Y., Tal, H. J. Dent. Res. (1992) [Pubmed]
  13. Agents for the management of plaque and gingivitis. Ciancio, S.G. J. Dent. Res. (1992) [Pubmed]
  14. Effect of daily rinsing with stannous fluoride on plaque and gingivitis: final report. Leverett, D.H., McHugh, W.D., Jensen, O.E. J. Dent. Res. (1984) [Pubmed]
  15. Influence of fluoride upon plaque and gingivitis in the beagle dog. McDonald, J.L., Schemehorn, B.R., Stookey, G.K. J. Dent. Res. (1978) [Pubmed]
  16. The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. Vogel, R.I., Lamster, I.B., Wechsler, S.A., Macedo, B., Hartley, L.J., Macedo, J.A. J. Periodontol. (1986) [Pubmed]
  17. Longitudinal changes in TCRB variable gene expression and markers of gingival inflammation in experimental gingivitis. Preshaw, P.M., Geatch, D.R., Lauffart, B., Jeffcoat, M.K., Taylor, J.J., Heasman, P.A. Journal of clinical periodontology. (1998) [Pubmed]
  18. Expression of estrogen receptors in desquamative gingivitis. Yih, W.Y., Richardson, L., Kratochvil, F.J., Avera, S.P., Zieper, M.B. J. Periodontol. (2000) [Pubmed]
  19. IgG subclass specific antibody response to periodontopathic organisms in HIV-positive patients. Yeung, S.C., Taylor, B.A., Sherson, W., Lazarus, R., Zhao, Z.Z., Bird, P.S., Hamlet, S.M., Bannon, M., Daly, C., Seymour, G.J. J. Periodontol. (2002) [Pubmed]
  20. Short-term effect of topical application of delmopinol on salivary microbiology, plaque, and gingivitis. Collaert, B., Attström, R., Edwardsson, S., Hase, J.C., Aström, M., Movert, R. Scandinavian journal of dental research. (1994) [Pubmed]
  21. Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis. Giannopoulou, C., Andersen, E., Demeurisse, C., Cimasoni, G. J. Dent. Res. (1992) [Pubmed]
  22. Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Zwadlo, G., Brüggen, J., Gerhards, G., Schlegel, R., Sorg, C. Clin. Exp. Immunol. (1988) [Pubmed]
  23. IL-4- and IL-6-producing cells in human periodontal disease tissue. Yamazaki, K., Nakajima, T., Gemmell, E., Polak, B., Seymour, G.J., Hara, K. J. Oral Pathol. Med. (1994) [Pubmed]
  24. Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients. Buduneli, N., Buduneli, E., Ciotanar, S., Atilla, G., Lappin, D., Kinane, D. Journal of clinical periodontology. (2004) [Pubmed]
  25. Characterization of matrix metalloproteinase (MMP-8 and -9) activities in the saliva and in gingival crevicular fluid of children with Down's syndrome. Halinen, S., Sorsa, T., Ding, Y., Ingman, T., Salo, T., Konttinen, Y.T., Saari, H. J. Periodontol. (1996) [Pubmed]
  26. Vascular endothelial growth factors and progression of periodontal diseases. Johnson, R.B., Serio, F.G., Dai, X. J. Periodontol. (1999) [Pubmed]
  27. Increased infiltration of CD1d and natural killer T cells in periodontal disease tissues. Amanuma, R., Nakajima, T., Yoshie, H., Yamazaki, K. J. Periodont. Res. (2006) [Pubmed]
  28. The systemic immune response is more prominent than the mucosal immune response in the pathogenesis of periodontal disease. Lappin, D.F., McGregor, A.M., Kinane, D.F. Journal of clinical periodontology. (2003) [Pubmed]
  29. Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation. Sculley, D.V., Langley-Evans, S.C. Clin. Sci. (2003) [Pubmed]
  30. The effect of triclosan on mediators of gingival inflammation. Gaffar, A., Scherl, D., Afflitto, J., Coleman, E.J. Journal of clinical periodontology. (1995) [Pubmed]
  31. Gingivitis, plaque accumulation and plaque composition under long-term use of Meridol. Zimmermann, A., Flores-de-Jacoby, L., Pan, P., Pan, P. Journal of clinical periodontology. (1993) [Pubmed]
  32. Acidogenicity of buccal plaque after a single rinse with amine fluoride - stannous fluoride mouthrinse solution. Damen, J.J., Buijs, M.J., ten Cate, J.M. Caries Res. (2002) [Pubmed]
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