- The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression. Wang, C., Thor, A.D., Moore, D.H., Zhao, Y., Kerschmann, R., Stern, R., Watson, P.H., Turley, E.A. Clin. Cancer Res. (1998)