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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene.

To elucidate the expression and regulation of the human type I Na+/phosphate transporter gene (NPT-1), the 5' flanking region of the NPT-1 gene was cloned, and its nucleotide sequence and function were determined. A genomic clone that contained approximately 14.0 kb of the 5'-flanking region of the NPT-1 gene was isolated. A single transcription start site was located 104 base pairs (bp) upstream of the 3' end of exon 1. In addition to the sequence of the 5'-flanking region contained a sequence weakly homologous to a TATA box at position -41 to -36 and many transcriptional regulatory elements. Transient expression revealed that a 45-bp region of proximal to exon 1, which contained TATA-like sequence, was sufficient for promoting luciferase expression in OK-cells derived from opossum kidney proximal tubule.[1]

References

  1. Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene. Taketani, Y., Miyamoto, K., Chikamori, M., Tanaka, K., Yamamoto, H., Tatsumi, S., Morita, K., Takeda, E. Biochim. Biophys. Acta (1998) [Pubmed]
 
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