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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pioneer axon guidance by UNC-129, a C. elegans TGF-beta.

The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.[1]

References

  1. Pioneer axon guidance by UNC-129, a C. elegans TGF-beta. Colavita, A., Krishna, S., Zheng, H., Padgett, R.W., Culotti, J.G. Science (1998) [Pubmed]
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