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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

unc-6  -  Protein UNC-6

Caenorhabditis elegans

 
 
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High impact information on unc-6

  • These errant trajectories depend on unc-6, which encodes a putative epidermal path cue, just as normal dorsally oriented axon trajectories do (such as those of certain motor neurons), suggesting that UNC-5 acts to reorient the touch cell growth cones by using its normal guidance mechanisms [1].
  • Genes have been identified that specify neuron type (for example cut and numb in Drosophila and mec-3 in Caenorhabditis elegans) and process guidance (for example, unc-5, unc-6 and unc-40 in C. elegans and the fas-1 gene of Drosophila) [2].
  • The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles [3].
  • In unc-6 and unc-40 mutants, leading edge formation fails, the cell remains symmetrical until late in development and the axon that eventually forms is misguided [4].
  • The chemotactic guidance factor encoded by the Caenorhabditis elegans unc-6 locus, whose mammalian homolog is Netrin, is perhaps the best known of the cell migration guidance factors [5].
 

Biological context of unc-6

  • Studies on one of these loci, acr-2, are described; acr-2 is located between sup-7 and unc-6 on the X chromosome [6].
 

Anatomical context of unc-6

  • This forms the basis of a genetic screen to identify other mutations that, like unc-6 mutations, suppress unc-5-induced growth cone guidance [7].
 

Other interactions of unc-6

  • The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans [8].
  • Comparing post-flight analyses of the DNA component fractionated, that is, amplification by PCR method, it revealed that the DNAs were separated approximately into two peaks: one of them contained seven-fold higher content of DNA estimated by a sod-4 gene probe than an unc-6 gene probe [9].

References

  1. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Hamelin, M., Zhou, Y., Su, M.W., Scott, I.M., Culotti, J.G. Nature (1993) [Pubmed]
  2. Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons. White, J.G., Southgate, E., Thomson, J.N. Nature (1992) [Pubmed]
  3. Pioneer axon guidance by UNC-129, a C. elegans TGF-beta. Colavita, A., Krishna, S., Zheng, H., Padgett, R.W., Culotti, J.G. Science (1998) [Pubmed]
  4. UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation. Adler, C.E., Fetter, R.D., Bargmann, C.I. Nat. Neurosci. (2006) [Pubmed]
  5. The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development. Montell, D.J. Development (1999) [Pubmed]
  6. Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2). Squire, M.D., Tornøe, C., Baylis, H.A., Fleming, J.T., Barnard, E.A., Sattelle, D.B. Recept. Channels (1995) [Pubmed]
  7. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Colavita, A., Culotti, J.G. Dev. Biol. (1998) [Pubmed]
  8. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Hedgecock, E.M., Culotti, J.G., Hall, D.H. Neuron (1990) [Pubmed]
  9. Bioprocessing in microgravity: free flow electrophoresis of C. elegans DNA. Kobayashi, H., Ishii, N., Nagaoka, S. J. Biotechnol. (1996) [Pubmed]
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