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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Altered membrane permeability as the basis of bactericidal action of methdilazine.

The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.[1]

References

  1. Altered membrane permeability as the basis of bactericidal action of methdilazine. Chattopadhyay, D., Mukherjee, T., Pal, P., Saha, B., Bhadra, R. J. Antimicrob. Chemother. (1998) [Pubmed]
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