Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Disyncram 10-[(1-methylpyrrolidin-3...

Synonyms: Tacaryl, Tacazyl, Tacryl, METHDILAZINE, Metodilazina, ...

Zhang, D. et al., Chattopadhyay, D. et al., Chakrabarty, A.N. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tacaryl

The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine [1].
Methdilazine (Md) could inhibit various Mycobacterium spp. at 5-15 micrograms/ml concentrations in vitro as well as in vivo [2].

High impact information on Tacaryl

Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans [3].
These experiments suggest that the sulfoxidation and hydroxylation of methdilazine and chlorpromazine by C. elegans are catalyzed by cytochrome P-450 [3].

References

Altered membrane permeability as the basis of bactericidal action of methdilazine. Chattopadhyay, D., Mukherjee, T., Pal, P., Saha, B., Bhadra, R. J. Antimicrob. Chemother. (1998) [Pubmed]
Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine. Chakrabarty, A.N., Bhattacharya, C.P., Dastidar, S.G. APMIS (1993) [Pubmed]
Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans. Zhang, D., Freeman, J.P., Sutherland, J.B., Walker, A.E., Yang, Y., Cerniglia, C.E. Appl. Environ. Microbiol. (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share