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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Repair kinetics of abasic sites in mammalian cells selectively monitored by the aldehyde reactive probe (ARP).

Human methylpurine N-glycosylase (MPG) activity was investigated by monitoring abasic (AP) sites resulting from removal of alkylated bases. The amount of AP sites in MMS-treated HeLa cells transiently increased at 3 h, then gradually decreased to 40% at 24 h. The presence of adenine, an inhibitor of AP endonucleases, in the repair incubation of MMS-treated cells induced moderate accumulation of AP sites, suggesting inhibition of the activities of MPG as well as AP endonucleases by adenine metabolites.[1]

References

  1. Repair kinetics of abasic sites in mammalian cells selectively monitored by the aldehyde reactive probe (ARP). Asaeda, A., Ide, H., Tano, K., Takamori, Y., Kubo, K. Nucleosides Nucleotides (1998) [Pubmed]
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