- Presence of mucosal change in the urinary bladder in nonhematuric patients with long-term exposure and/or accumulating high-dose cyclophosphamide. Possible significance of follow-up cystoscopy on preventing development of cyclophosphamide-induced hemorrhagic cystitis. Kimura, M., Tomita, Y., Morishita, H., Takahashi, K. Urologia internationalis. (1998)