Disease relevance of Cystitis

• Thus, CGA is broadly disseminated and contributes to co-trimoxazole resistance in pyelonephritis as well as in cystitis [1].
• Image of the month. Congenital colonic duplication, sigmoid volvulus, Meckel's diverticulum, and emphysematous cystitis are considered in the differential diagnosis before surgery [2].
• Lupus cystitis: primary bladder manifestations of systemic lupus erythematosus [3].
• Use of Lactobacillus strains resistant to Nonoxynol-9, a spermicide that kills members of the protective normal vaginal flora, may have potential for use in women with recurrent cystitis using this contraceptive agent [4].
• At the melphalan dose of 90 mg/m2, grade greater than or equal to 3 regimen-related toxicity (RRT) was observed in five patients (31%; 95% confidence interval [CI], 11% to 59%), with hepatic (venoocclusive disease [VOD]) and urinary (hemorrhagic cystitis) RRT being the most frequent complications [5].

Psychiatry related information on Cystitis

• How does cystitis affect a comparative risk profile of tiaprofenic acid with other non-steroidal antiinflammatory drugs? An international study based on spontaneous reports and drug usage data. ADR Signals Analysis Project (ASAP) Team [6].

High impact information on Cystitis

• Patients treated with intravenous cyclophosphamide have not experienced hemorrhagic cystitis, cancer, or a disproportionate number of major infections [7].
• Urine specimens from 61 women with symptoms of cystitis who are infected with amoxicillin-sensitive organisms were examined by the antibody-coated bacteria assay [8].
• CONCLUSIONS: While the prevalence of resistance to trimethoprim-sulfamethoxazole, ampicillin, and cephalothin increased significantly among uropathogens causing acute cystitis, resistance to nitrofurantoin and ciprofloxacin remained infrequent [9].
• CONCLUSIONS--A 3-day regimen of trimethoprim-sulfamethoxazole is more effective and less expensive than 3-day regimens of nitrofurantoin, cefadroxil, or amoxicillin for treatment of uncomplicated cystitis in women [10].
• Acute hemorrhagic cystitis. Industrial exposure to the pesticide chlordimeform [11].

Chemical compound and disease context of Cystitis

• Delayed cystitis due to cyclophosphamide [12].
• Therapy for acute cystitis in adult women. Randomized comparison of single-dose sulfisoxazole vs trimethoprim-sulfamethoxazole [13].
• We evaluated single-dose regimens of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin as treatment for acute cystitis in 38 women [14].
• Piperacillin and haemorrhagic cystitis [15].
• Carbenicillin-induced haemorrhagic cystitis [16].

Biological context of Cystitis

• Although previous reports had suggested that the sulfhydryl-containing compound mesna might be superior to forced diuresis in preventing hemorrhagic cystitis, there were concerns about the effect of mesna on engraftment in these studies [17].
• A novel murine model of UTI reinfection was developed using the prototypic cystitis UPEC isolate NU14 harboring a plasmid encoding OVA as a unique antigenic marker [18].
• Other grade 3 and 4 toxicities were anemia, thrombocytopenia, fatigue, prolonged partial thromboplastin time, hemorrhagic cystitis, dysuria, and urinary frequency [19].
• Melatonin exhibited significant protection against CP-induced cystitis by diminishing bladder oxidative stress and blocking iNOS and peroxynitrite production [20].
• The recent discovery that allele III of papG (the P fimbrial adhesin gene) predominates among human cystitis isolates and confers an adherence phenotype resembling that of canine ExPEC prompted the present reevaluation of the canine-human ExPEC connection [21].

Anatomical context of Cystitis

• PURPOSE: To compare the use of intravenous (IV) hydration plus either continuous bladder irrigation or mesna for the prevention of hemorrhagic cystitis in the bone marrow transplant setting [22].
• Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis [23].
• We compared the safety and efficacy of a single 400-mg dose of ofloxacin, ofloxacin (200 mg) once daily for 3 days, and trimethoprim-sulfamethoxazole (160:800 mg) twice daily for 7 days for the treatment of acute uncomplicated cystitis (urinary tract infection [UTI]) in women [24].
• The cystitis strains induced significantly less IL-6 than did the laboratory E. coli strain MG1655 from 5637 and T24 bladder epithelial cells [25].
• Type 1 and type 2 chain A antigens and type 1 chain H antigens were deleted from urothelium in a significant (p less than 0.05) number of patients with chronic cystitis, and Lea (partly sialylated) expression was extended from the luminal cell layer to all cell layers [26].

Gene context of Cystitis

• The availability of mice genetically deficient in neurokinin-1 receptor (NK-1R(-/-)) allows us to directly evaluate the importance of substance P in cystitis [27].
• Neurotrophin/Trk interactions in the bladder and MPG may contribute to bladder overactivity with cystitis [28].
• Further, the amounts of urine EGF and IGF1 were also elevated in IC patients as compared to patients with bacterial cystitis, and urine IGFBP3 levels were significantly elevated when expressed per milligram of urine creatinine [29].
• CONCLUSIONS: Cystitis decreases bladder NGF and BDNF expression, whereas MPG expression is increased [28].
• Serum amyloid A: a novel serum marker for the detection of systemic inflammatory response in cystitis [30].

Analytical, diagnostic and therapeutic context of Cystitis

• Based on this randomized trial of 100 patients, we conclude that mesna and hyperhydration are equally effective in preventing cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation patients [17].
• In a series of 111 patients with Wegener's granulomatosis who were given cyclophosphamide therapy, hemorrhagic cystitis, diagnosed on the basis of gross hematuria or at cystoscopy (or both), developed in 17 (15%) [31].
• Experimental cystitis was induced in female mice by intravesical instillation of SP, LPS, or fluorescein-labeled LPS [32].
• The prognosis of emphysematous cystitis is good after early diagnosis and prompt treatment with appropriate antibiotics, blood glucose control, and adequate urinary drainage [33].
• This study assessed the relative involvement of the two bradykinin (Bk) receptors (B1 and B2) in the viscero-visceral hyper-reflexia (VVH) and plasma extravasation observed in an animal model of cystitis [34].

References