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Disease relevance of Cystitis


Psychiatry related information on Cystitis

  • How does cystitis affect a comparative risk profile of tiaprofenic acid with other non-steroidal antiinflammatory drugs? An international study based on spontaneous reports and drug usage data. ADR Signals Analysis Project (ASAP) Team [6].

High impact information on Cystitis


Chemical compound and disease context of Cystitis


Biological context of Cystitis

  • Although previous reports had suggested that the sulfhydryl-containing compound mesna might be superior to forced diuresis in preventing hemorrhagic cystitis, there were concerns about the effect of mesna on engraftment in these studies [17].
  • A novel murine model of UTI reinfection was developed using the prototypic cystitis UPEC isolate NU14 harboring a plasmid encoding OVA as a unique antigenic marker [18].
  • Other grade 3 and 4 toxicities were anemia, thrombocytopenia, fatigue, prolonged partial thromboplastin time, hemorrhagic cystitis, dysuria, and urinary frequency [19].
  • Melatonin exhibited significant protection against CP-induced cystitis by diminishing bladder oxidative stress and blocking iNOS and peroxynitrite production [20].
  • The recent discovery that allele III of papG (the P fimbrial adhesin gene) predominates among human cystitis isolates and confers an adherence phenotype resembling that of canine ExPEC prompted the present reevaluation of the canine-human ExPEC connection [21].

Anatomical context of Cystitis

  • PURPOSE: To compare the use of intravenous (IV) hydration plus either continuous bladder irrigation or mesna for the prevention of hemorrhagic cystitis in the bone marrow transplant setting [22].
  • Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis [23].
  • We compared the safety and efficacy of a single 400-mg dose of ofloxacin, ofloxacin (200 mg) once daily for 3 days, and trimethoprim-sulfamethoxazole (160:800 mg) twice daily for 7 days for the treatment of acute uncomplicated cystitis (urinary tract infection [UTI]) in women [24].
  • The cystitis strains induced significantly less IL-6 than did the laboratory E. coli strain MG1655 from 5637 and T24 bladder epithelial cells [25].
  • Type 1 and type 2 chain A antigens and type 1 chain H antigens were deleted from urothelium in a significant (p less than 0.05) number of patients with chronic cystitis, and Lea (partly sialylated) expression was extended from the luminal cell layer to all cell layers [26].

Gene context of Cystitis

  • The availability of mice genetically deficient in neurokinin-1 receptor (NK-1R(-/-)) allows us to directly evaluate the importance of substance P in cystitis [27].
  • Neurotrophin/Trk interactions in the bladder and MPG may contribute to bladder overactivity with cystitis [28].
  • Further, the amounts of urine EGF and IGF1 were also elevated in IC patients as compared to patients with bacterial cystitis, and urine IGFBP3 levels were significantly elevated when expressed per milligram of urine creatinine [29].
  • CONCLUSIONS: Cystitis decreases bladder NGF and BDNF expression, whereas MPG expression is increased [28].
  • Serum amyloid A: a novel serum marker for the detection of systemic inflammatory response in cystitis [30].

Analytical, diagnostic and therapeutic context of Cystitis


  1. A disseminated multidrug-resistant clonal group of uropathogenic Escherichia coli in pyelonephritis. Johnson, J.R., Manges, A.R., O'Bryan, T.T., Riley, L.W. Lancet (2002) [Pubmed]
  2. Image of the month. Congenital colonic duplication, sigmoid volvulus, Meckel's diverticulum, and emphysematous cystitis are considered in the differential diagnosis before surgery. Mehta, S., Barkun, A.N. Gastroenterology (1997) [Pubmed]
  3. Lupus cystitis: primary bladder manifestations of systemic lupus erythematosus. Orth, R.W., Weisman, M.H., Cohen, A.H., Talner, L.B., Nachtsheim, D., Zvaifler, N.J. Ann. Intern. Med. (1983) [Pubmed]
  4. Is there a role for lactobacilli in prevention of urogenital and intestinal infections? Reid, G., Bruce, A.W., McGroarty, J.A., Cheng, K.J., Costerton, J.W. Clin. Microbiol. Rev. (1990) [Pubmed]
  5. Busulfan, cyclophosphamide, and melphalan conditioning for autologous bone marrow transplantation in hematologic malignancy. Phillips, G.L., Shepherd, J.D., Barnett, M.J., Lansdorp, P.M., Klingemann, H.G., Spinelli, J.J., Nevill, T.J., Chan, K.W., Reece, D.E. J. Clin. Oncol. (1991) [Pubmed]
  6. How does cystitis affect a comparative risk profile of tiaprofenic acid with other non-steroidal antiinflammatory drugs? An international study based on spontaneous reports and drug usage data. ADR Signals Analysis Project (ASAP) Team. Lindquist, M., Pettersson, M., Edwards, I.R., Sanderson, J.H., Taylor, N.F., Fletcher, A.P., Schou, J.S., Savage, R. Pharmacol. Toxicol. (1997) [Pubmed]
  7. Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. Austin, H.A., Klippel, J.H., Balow, J.E., le Riche, N.G., Steinberg, A.D., Plotz, P.H., Decker, J.L. N. Engl. J. Med. (1986) [Pubmed]
  8. Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technic. Fang, L.S., Tolkoff-Rubin, N.E., Rubin, R.H. N. Engl. J. Med. (1978) [Pubmed]
  9. Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women. Gupta, K., Scholes, D., Stamm, W.E. JAMA (1999) [Pubmed]
  10. Randomized comparative trial and cost analysis of 3-day antimicrobial regimens for treatment of acute cystitis in women. Hooton, T.M., Winter, C., Tiu, F., Stamm, W.E. JAMA (1995) [Pubmed]
  11. Acute hemorrhagic cystitis. Industrial exposure to the pesticide chlordimeform. Folland, D.S., Kimbrough, R.D., Cline, R.E., Swiggart, R.C., Schaffner, W. JAMA (1978) [Pubmed]
  12. Delayed cystitis due to cyclophosphamide. Armstrong, B., Resnick, M.I., Richards, F. N. Engl. J. Med. (1979) [Pubmed]
  13. Therapy for acute cystitis in adult women. Randomized comparison of single-dose sulfisoxazole vs trimethoprim-sulfamethoxazole. Buckwold, F.J., Ludwig, P., Harding, G.K., Thompson, L., Slutchuk, M., Shaw, J., Ronald, A.R. JAMA (1982) [Pubmed]
  14. Single-dose therapy for cystitis in women. A comparison of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin. Hooton, T.M., Running, K., Stamm, W.E. JAMA (1985) [Pubmed]
  15. Piperacillin and haemorrhagic cystitis. Joy, V.A. Lancet (1979) [Pubmed]
  16. Carbenicillin-induced haemorrhagic cystitis. Møller, N.E. Lancet (1978) [Pubmed]
  17. Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. Shepherd, J.D., Pringle, L.E., Barnett, M.J., Klingemann, H.G., Reece, D.E., Phillips, G.L. J. Clin. Oncol. (1991) [Pubmed]
  18. Antigen-specific responses accelerate bacterial clearance in the bladder. Thumbikat, P., Waltenbaugh, C., Schaeffer, A.J., Klumpp, D.J. J. Immunol. (2006) [Pubmed]
  19. Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Posey, J.A., Saif, M.W., Carlisle, R., Goetz, A., Rizzo, J., Stevenson, S., Rudoltz, M.S., Kwiatek, J., Simmons, P., Rowinsky, E.K., Takimoto, C.H., Tolcher, A.W. Clin. Cancer Res. (2005) [Pubmed]
  20. Melatonin ameliorates bladder damage induced by cyclophosphamide in rats. Topal, T., Oztas, Y., Korkmaz, A., Sadir, S., Oter, S., Coskun, O., Bilgic, H. J. Pineal Res. (2005) [Pubmed]
  21. Evidence of commonality between canine and human extraintestinal pathogenic Escherichia coli strains that express papG allele III. Johnson, J.R., O'Bryan, T.T., Low, D.A., Ling, G., Delavari, P., Fasching, C., Russo, T.A., Carlino, U., Stell, A.L. Infect. Immun. (2000) [Pubmed]
  22. Mesna compared with continuous bladder irrigation as uroprotection during high-dose chemotherapy and transplantation: a randomized trial. Vose, J.M., Reed, E.C., Pippert, G.C., Anderson, J.R., Bierman, P.J., Kessinger, A., Spinolo, J., Armitage, J.O. J. Clin. Oncol. (1993) [Pubmed]
  23. Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. Ulich, T.R., Whitcomb, L., Tang, W., O'Conner Tressel, P., Tarpley, J., Yi, E.S., Lacey, D. Cancer Res. (1997) [Pubmed]
  24. Single-dose and three-day regimens of ofloxacin versus trimethoprim-sulfamethoxazole for acute cystitis in women. Hooton, T.M., Johnson, C., Winter, C., Kuwamura, L., Rogers, M.E., Roberts, P.L., Stamm, W.E. Antimicrob. Agents Chemother. (1991) [Pubmed]
  25. Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Hunstad, D.A., Justice, S.S., Hung, C.S., Lauer, S.R., Hultgren, S.J. Infect. Immun. (2005) [Pubmed]
  26. Loss of blood group ABO-related antigen expression in urothelium from patients with chronic cystitis. Orntoft, T.F., Hvid, H., Clausen, H., Hakomori, S., Dabelsteen, E. Lab. Invest. (1989) [Pubmed]
  27. Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. Saban, R., Saban, M.R., Nguyen, N.B., Lu, B., Gerard, C., Gerard, N.P., Hammond, T.G. Am. J. Pathol. (2000) [Pubmed]
  28. Cyclophosphamide induced cystitis alters neurotrophin and receptor tyrosine kinase expression in pelvic ganglia and bladder. Murray, E., Malley, S.E., Qiao, L.Y., Hu, V.Y., Vizzard, M.A. J. Urol. (2004) [Pubmed]
  29. Concentrations of specific epithelial growth factors in the urine of interstitial cystitis patients and controls. Keay, S., Zhang, C.O., Kagen, D.I., Hise, M.K., Jacobs, S.C., Hebel, J.R., Gordon, D., Whitmore, K., Bodison, S., Warren, J.W. J. Urol. (1997) [Pubmed]
  30. Serum amyloid A: a novel serum marker for the detection of systemic inflammatory response in cystitis. Lannergard, A., Friman, G., Larsson, A. J. Urol. (2003) [Pubmed]
  31. Cyclophosphamide-induced bladder toxicity in Wegener's granulomatosis. Stillwell, T.J., Benson, R.C., DeRemee, R.A., McDonald, T.J., Weiland, L.H. Arthritis Rheum. (1988) [Pubmed]
  32. LPS-sensory peptide communication in experimental cystitis. Saban, M.R., Saban, R., Hammond, T.G., Haak-Frendscho, M., Steinberg, H., Tengowski, M.W., Bjorling, D.E. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  33. Emphysematous cystitis and pyelitis in a diabetic renal transplant recipient. Akalin, E., Hyde, C., Schmitt, G., Kaufman, J., Hamburger, R.J. Transplantation (1996) [Pubmed]
  34. The modulatory effects of bradykinin B1 and B2 receptor antagonists upon viscero-visceral hyper-reflexia in a rat model of visceral hyperalgesia. Jaggar, S.I., Habib, S., Rice, A.S. Pain (1998) [Pubmed]
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