T cell adhesion to the extracellular matrix proteins as a determinant of pregnancy success or failure.
Recent studies emphasize an important role of the extracellular matrix ( ECM) proteins in the regulation of T cell function. The role of the T cell:ECM interaction during pregnancy has not been established yet. ECM proteins promote acquisition of the adhesive and degradive properties required by the embryo for successful implantation. T cells presented at the maternal-foetal interface may regulate the maternal immune response to the foetal allograft. T cell adhesion to collagen IV (C-IV), elastin ( E) and fibronectin in 35 women with threatened abortion and in five normal pregnant women were studied. The relationship between T cell adhesion to ECM and pregnancy outcome was analyzed. Correlation between T cell adhesion to fibronectin and C-IV and pregnancy success or failure were observed. Our studies indicate that there is enhanced T cell adhesion to C-IV and fibronectin in women with unexplained threatened abortion, especially in those with a previous history of recurrent spontaneous abortion (RSA).[1]References
- T cell adhesion to the extracellular matrix proteins as a determinant of pregnancy success or failure. Małgorzata, J., Górski, A. Immunol. Lett. (1998) [Pubmed]
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