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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin.

CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that swertiamarin and mangiferin antagonize each other in vivo and thereby reverse their CNS effects.[1]

References

  1. Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin. Bhattacharya, S.K., Reddy, P.K., Ghosal, S., Singh, A.K., Sharma, P.V. Journal of pharmaceutical sciences. (1976) [Pubmed]
 
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