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Chemical Compound Review

AC1NSXU9     1,3,6,7-tetrahydroxy-2- [(2S,3R,4S,5S,6R)-3...

Synonyms: CHEMBL455364, CHEBI:545147, DNC013871
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Disease relevance of Mangiferin

  • Here, we report that mangiferin and morin, two antioxidant polyphenols, are neuroprotective in both in vitro and in vivo models of ischemia [1].
  • Mangiferin (MGN), a glucosylxanthone derived from Mangifera indica (mango), was investigated for its ability to reduce the frequency of radiation-induced micronucleated binucleate cells (MNBNCs) in cultured human peripheral blood lymphocytes (HPBLs) [2].
  • These results are of pharmacological relevance since mangiferin and its naturally contained extracts could be potential candidates for chelation therapy in diseases related to abnormal intracellular iron distribution or iron overload [3].
  • In the long-term assay, the group treated with 0.1% mangiferin in initiation phase of the experimental protocol had significantly lower incidence and multiplicity of intestinal neoplasms induced by AOM (47.3 and 41.8% reductions of the group treated with AOM alone for incidence and multiplicity, respectively) [4].
  • Mangiferin was also found to antagonize in vitro the cytopathic effect of HIV [5].

High impact information on Mangiferin

  • Mangiferin-mediated down-regulation of NF-kappaB also potentiates chemotherapeutic agent-mediated cell death, suggesting a role in combination therapy for cancer [6].
  • Mangiferin, a natural polyphenol is known to exhibit anti-inflammatory, antioxidant, and antiviral effects [6].
  • Mangiferin, similar to the other known antioxidants, NAC and PDTC, inhibits TNF-induced reactive oxygen intermediate (ROI) generation [6].
  • Cell death caused by glutamate in neuronal cultures was decreased in the presence of submicromolar concentrations of mangiferin or morin which in turn attenuated receptor-mediated calcium influx, oxidative stress as well as apoptosis [1].
  • Nanomolar concentrations of mangiferin and morin, two natural polyphenols with antioxidant properties, partially protect oligodendrocytes as well as cortical neurons from mild, but not intense, insults mediated by AMPA receptors [7].

Chemical compound and disease context of Mangiferin


Biological context of Mangiferin


Anatomical context of Mangiferin


Associations of Mangiferin with other chemical compounds


Gene context of Mangiferin

  • This study investigated the effects of the natural polyphenol mangiferin (MA) on superoxide anion (O(2)(-)) production, xanthine oxidase (XO) activity, vascular contractility, inducible nitric oxide synthase (iNOS) mRNA levels, tumour necrosis factor-alpha (TNF-alpha) mRNA levels, and tumour growth factor-beta (TGF-beta) mRNA levels [21].
  • (Anacardiaceae; Vimang), which contains a defined mixture of components including polyphenols (principally mangiferin, MA), triterpenes, phytosteroids, fatty acids and microelements, on expression of inflammation mediators in inflammatory murine macrophages after stimulation in vitro with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) [22].
  • Mangiferin also inhibited systemic TNFalpha at 20 mg kg(-1) [23].
  • Mangiferin did no affect either IgM or IgG2a, but significantly enhanced production of IgG1 and IgG2b [24].
  • An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved [25].

Analytical, diagnostic and therapeutic context of Mangiferin


  1. Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia. Gottlieb, M., Leal-Campanario, R., Campos-Esparza, M.R., Sánchez-Gómez, M.V., Alberdi, E., Arranz, A., Delgado-García, J.M., Gruart, A., Matute, C. Neurobiol. Dis. (2006) [Pubmed]
  2. Effect of mangiferin on radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes. Jagetia, G.C., Venkatesha, V.A. Environ. Mol. Mutagen. (2005) [Pubmed]
  3. Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate. Andreu, G.P., Delgado, R., Velho, J.A., Curti, C., Vercesi, A.E. Eur. J. Pharmacol. (2005) [Pubmed]
  4. The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Yoshimi, N., Matsunaga, K., Katayama, M., Yamada, Y., Kuno, T., Qiao, Z., Hara, A., Yamahara, J., Mori, H. Cancer Lett. (2001) [Pubmed]
  5. Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. Guha, S., Ghosal, S., Chattopadhyay, U. Chemotherapy. (1996) [Pubmed]
  6. beta-D-Glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor kappaB but potentiates apoptosis. Sarkar, A., Sreenivasan, Y., Ramesh, G.T., Manna, S.K. J. Biol. Chem. (2004) [Pubmed]
  7. Differential oxidative stress in oligodendrocytes and neurons after excitotoxic insults and protection by natural polyphenols. Ibarretxe, G., Sánchez-Gómez, M.V., Campos-Esparza, M.R., Alberdi, E., Matute, C. Glia (2006) [Pubmed]
  8. Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond. Sanugul, K., Akao, T., Li, Y., Kakiuchi, N., Nakamura, N., Hattori, M. Biol. Pharm. Bull. (2005) [Pubmed]
  9. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Zheng, M.S., Lu, Z.Y. Chin. Med. J. (1990) [Pubmed]
  10. The effect of Kampo formulae on bone resorption in vitro and in vivo. I. Active constituents of Tsu-kan-gan. Li, H., Miyahara, T., Tezuka, Y., Namba, T., Nemoto, N., Tonami, S., Seto, H., Tada, T., Kadota, S. Biol. Pharm. Bull. (1998) [Pubmed]
  11. Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats. Prabhu, S., Jainu, M., Sabitha, K.E., Devi, C.S. Journal of ethnopharmacology. (2006) [Pubmed]
  12. Fe(III) Shifts the Mitochondria Permeability Transition-Eliciting Capacity of Mangiferin to Protection of Organelle. Pardo-Andreu, G.L., Cavalheiro, R.A., Dorta, D.J., Naal, Z., Delgado, R., Vercesi, A.E., Curti, C. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  13. Pharmacokinetic study of free mangiferin in rats by microdialysis coupled with microbore high-performance liquid chromatography and tandem mass spectrometry. Lai, L., Lin, L.C., Lin, J.H., Tsai, T.H. Journal of chromatography. A. (2003) [Pubmed]
  14. Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats. Muruganandan, S., Gupta, S., Kataria, M., Lal, J., Gupta, P.K. Toxicology (2002) [Pubmed]
  15. Mangiferin, a natural occurring glucosyl xanthone, increases susceptibility of rat liver mitochondria to calcium-induced permeability transition. Andreu, G.L., Delgado, R., Velho, J.A., Curti, C., Vercesi, A.E. Arch. Biochem. Biophys. (2005) [Pubmed]
  16. Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines. Tang, S.Y., Whiteman, M., Peng, Z.F., Jenner, A., Yong, E.L., Halliwell, B. Free Radic. Biol. Med. (2004) [Pubmed]
  17. A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas. van der Merwe, J.D., Joubert, E., Richards, E.S., Manley, M., Snijman, P.W., Marnewick, J.L., Gelderblom, W.C. Mutat. Res. (2006) [Pubmed]
  18. Mangiferin and chlorogenic Acid from hypericum species. Seabra, R.M., Alves, A.C. Planta Med. (1989) [Pubmed]
  19. Secoiridoids and Xanthones from Gentianella nitida. Lacaille-Dubois, M.A., Galle, K., Wagner, H. Planta Med. (1996) [Pubmed]
  20. Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush (Cyclopia genistoides) plant material. Joubert, E., Manley, M., Botha, M. J. Agric. Food Chem. (2006) [Pubmed]
  21. In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-alpha and transforming growth factor-beta genes. Leiro, J.M., Alvarez, E., Arranz, J.A., Siso, I.G., Orallo, F. Biochem. Pharmacol. (2003) [Pubmed]
  22. An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages. Leiro, J., García, D., Arranz, J.A., Delgado, R., Sanmartín, M.L., Orallo, F. Int. Immunopharmacol. (2004) [Pubmed]
  23. Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG). Role of mangiferin isolated from the extract. Garrido, G., Delgado, R., Lemus, Y., Rodríguez, J., García, D., Núñez-Sellés, A.J. Pharmacol. Res. (2004) [Pubmed]
  24. Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses. García, D., Leiro, J., Delgado, R., Sanmartín, M.L., Ubeira, F.M. Phytotherapy research : PTR. (2003) [Pubmed]
  25. Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin. Bhattacharya, S.K., Reddy, P.K., Ghosal, S., Singh, A.K., Sharma, P.V. Journal of pharmaceutical sciences. (1976) [Pubmed]
  26. The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes. Miura, T., Iwamoto, N., Kato, M., Ichiki, H., Kubo, M., Komatsu, Y., Ishida, T., Okada, M., Tanigawa, K. Biol. Pharm. Bull. (2001) [Pubmed]
  27. Pharmacokinetics of mangiferin in rat plasma after oral administration of a single dose of suanzaoren decoction. Li, Y.J., Bi, K.S. Yao Xue Xue Bao (2005) [Pubmed]
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