Disease relevance of BRN 0055278

• While swertiamarin was also active against Proteus mirabilis and Serratia marcescens, sweroside inhibited the growth of Staphylococcus epidermidis [1].

High impact information on BRN 0055278

• The contents of gentiopicroside and swertiamarin, the two important secoiridoid glucosides, in different plant material were determined by high performance liquid chromatography (HPLC) [2].
• CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated [3].
• Subsequently, we applied the same analytical condition to estimate the swertiamarin contents in Japanese pharmacopoeia stomachic preparations, in OTC gastroenteric drugs and in OTC hair tonics containing Swertia herb [4].
• To date, papers have described the discrimination of Swertia herbs from other bitter crude drugs, estimation of swertiamarin and seasonal variation in swertiamarin content using thin-layer chromatography, while other papers have reported quantitative determination of swertiamarin using high-performance liquid chromatography (HPLC) [4].

Associations of BRN 0055278 with other chemical compounds

• From the aerial parts of GENTIANA GELIDA two new strongly bitter acylsecoiridoid glucosides, gelidoside ( 1) and gentomoside ( 2), have been isolated along with five known secoiridoid glucosides, trifloroside ( 3), gentiopicroside ( 4), swertiamarin ( 5), eustomoside ( 6), and eustomorusside ( 7) [5].

Analytical, diagnostic and therapeutic context of BRN 0055278

• Analysis of swertiamarin in Swertia herb and preparations containing this crude drug by capillary electrophoresis [4].

References