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Disease relevance of Swertia


High impact information on Swertia


Biological context of Swertia


Associations of Swertia with chemical compounds


Gene context of Swertia

  • Our preliminary findings revealed that DT and RT correlated well with IL-1alpha, TNF-alpha and IL-10 levels in the joint homogenates of arthritic mice and after therapy with Swertia chirayita extracts [12].
  • Hepatoprotective principles of Swertia japonica Makino on D-galactosamine/lipopolysaccharide-induced liver injury in mice [13].
  • Reinvestigation of the plant, Swertia decussata resulted in the isolation of four antioxidant xanthones, which were characterized as 1-hydroxy-3,7,8-trimethoxy, 1,8-dihydroxy-3,7-dimethoxy, 1,7-dihydroxy-3,8-dimethoxy and 1,7,8-trihydroxy-3-methoxyxanthones [14].
  • Subsequently, we applied the same analytical condition to estimate the swertiamarin contents in Japanese pharmacopoeia stomachic preparations, in OTC gastroenteric drugs and in OTC hair tonics containing Swertia herb [15].
  • This is the fi rst report of its kind and the observation suggests the chemopreventive potential of Swertia chirata [16].

Analytical, diagnostic and therapeutic context of Swertia


  1. Protective effects of demethylbellidifolin on myocardial ischemia-reperfusion injury in rats. Jiang, D.J., Tan, G.S., Zhou, Z.H., Xu, K.P., Ye, F., Li, Y.J. Planta Med. (2002) [Pubmed]
  2. Inhibitory effect of tetrahydroswertianolin on tumor necrosis factor-alpha-dependent hepatic apoptosis in mice. Hase, K., Xiong, Q., Basnet, P., Namba, T., Kadota, S. Biochem. Pharmacol. (1999) [Pubmed]
  3. Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level. Jiang, D.J., Jiang, J.L., Tan, G.S., Huang, Z.Z., Deng, H.W., Li, Y.J. Planta Med. (2003) [Pubmed]
  4. Production of amarogentin in root cultures of Swertia chirata. Keil, M., Härtle, B., Guillaume, A., Psiorz, M. Planta Med. (2000) [Pubmed]
  5. Secoiridoid glucosides from Swertia mileensis. Kikuzaki, H., Kawasaki, Y., Kitamura, S., Nakatani, N. Planta Med. (1996) [Pubmed]
  6. Bellidifolin stimulates glucose uptake in rat 1 fibroblasts and ameliorates hyperglycemia in streptozotocin (STZ)-induced diabetic rats. Basnet, P., Kadota, S., Shimizu, M., Takata, Y., Kobayashi, M., Namba, T. Planta Med. (1995) [Pubmed]
  7. Protective effect of swerchirin on hematopoiesis in 60Co-irradiated mice. Ya, B.Q., Nian, L.C., Li, C., Gen, X.P. Phytomedicine (1999) [Pubmed]
  8. Metabolism of swertiamarin from Swertia japonica by human intestinal bacteria. el-Sedawy, A.I., Shu, Y.Z., Hattori, M., Kobashi, K., Namba, T. Planta Med. (1989) [Pubmed]
  9. Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita. Bajpai, M.B., Asthana, R.K., Sharma, N.K., Chatterjee, S.K., Mukherjee, S.K. Planta Med. (1991) [Pubmed]
  10. Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata. Wang, C.Z., Maier, U.H., Keil, M., Zenk, M.H., Bacher, A., Rohdich, F., Eisenreich, W. Eur. J. Biochem. (2003) [Pubmed]
  11. Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Basnet, P., Kadota, S., Shimizu, M., Namba, T. Planta Med. (1994) [Pubmed]
  12. Correlation of cytokine and mobility in mice with arthritis and during therapy with Swertia chirayita. Kumar, P., Paul, B., Kumar, S., Ali, M., Sexana, A.K. Journal of herbal pharmacotherapy. (2004) [Pubmed]
  13. Hepatoprotective principles of Swertia japonica Makino on D-galactosamine/lipopolysaccharide-induced liver injury in mice. Hase, K., Li, J., Basnet, P., Xiong, Q., Takamura, S., Namba, T., Kadota, S. Chem. Pharm. Bull. (1997) [Pubmed]
  14. Structural confirmation of decussatin, a Swertia decussata xanthone. Chintalwar, G.J., Chattopadhyay, S. Nat. Prod. Res. (2006) [Pubmed]
  15. Analysis of swertiamarin in Swertia herb and preparations containing this crude drug by capillary electrophoresis. Takei, H., Nakauchi, K., Yoshizaki, F. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2001) [Pubmed]
  16. Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis model. Saha, P., Mandal, S., Das, A., Das, P.C., Das, S. Phytotherapy research : PTR. (2004) [Pubmed]
  17. Two new iridoid glycosides from the Tibetan folk medicine Swertia franchetiana. Wang, S.S., Zhao, W.J., Han, X.W., Liang, X.M. Chem. Pharm. Bull. (2005) [Pubmed]
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