Disease relevance of Swertia

• The effect of demethylbellidifolin (DMB), a major compound of Swertia davidi Franch, on ischemia-reperfusion injury was studied in rats [1].

High impact information on Swertia

• We investigated the effect of tetrahydroswertianolin (THS), a hepatoprotective agent from Swertia japonica, on tumor necrosis factor-alpha (TNF-alpha)-dependent hepatic apoptosis induced by D-galactosamine (D-GalN) (700 mg/kg, i.p.) and lipopolysaccharide (LPS) (10 microg/kg, i.p.) in mice [2].
• The effect of demethylbellidifolin (DMB), a major compound of Swertia davidi Franch, on the adhesion of monocytes to endothelial cells induced by oxidized low-density lipoprotein (ox-LDL) was studied [3].
• Production of amarogentin in root cultures of Swertia chirata [4].
• Five new acyl secoiridoid glucosides along with three known secoiridoid glucosides, swertiamarin, 2'-O-acetylswertiamarin, and amarogentin, were isolated from the aerial parts of Swertia mileensis [5].
• Bellidifolin, isolated from Swertia japonica, was found to be a potent hypoglycemic agent in STZ-induced diabetic rats by both oral and intraperitoneal administration [6].

Biological context of Swertia

• The protective effect of swerchirin, a purified xanthone isolated from whole herb of Swertia calycina Franch. on hematopoiesis was investigated [7].

Associations of Swertia with chemical compounds

• Metabolism of swertiamarin from Swertia japonica by human intestinal bacteria [8].
• Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita [9].
• A xanthone was isolated from the hexane fraction of the Swertia chirayita plant and identified as 1,8-dihydroxy-3,5-dimethoxyxanthone (swerchirin) [9].
• Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata [10].
• Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica [11].

Gene context of Swertia

• Our preliminary findings revealed that DT and RT correlated well with IL-1alpha, TNF-alpha and IL-10 levels in the joint homogenates of arthritic mice and after therapy with Swertia chirayita extracts [12].
• Hepatoprotective principles of Swertia japonica Makino on D-galactosamine/lipopolysaccharide-induced liver injury in mice [13].
• Reinvestigation of the plant, Swertia decussata resulted in the isolation of four antioxidant xanthones, which were characterized as 1-hydroxy-3,7,8-trimethoxy, 1,8-dihydroxy-3,7-dimethoxy, 1,7-dihydroxy-3,8-dimethoxy and 1,7,8-trihydroxy-3-methoxyxanthones [14].
• Subsequently, we applied the same analytical condition to estimate the swertiamarin contents in Japanese pharmacopoeia stomachic preparations, in OTC gastroenteric drugs and in OTC hair tonics containing Swertia herb [15].
• This is the fi rst report of its kind and the observation suggests the chemopreventive potential of Swertia chirata [16].

Analytical, diagnostic and therapeutic context of Swertia

• Two new iridoid glycosides from the Tibetan folk medicine Swertia franchetiana [17].
• Analysis of swertiamarin in Swertia herb and preparations containing this crude drug by capillary electrophoresis [15].

References