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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease.

Familial calcium pyrophosphate dihydrate deposition disease (CPPDD) is a disease of articular cartilage that is radiographically characterized by chondrocalcinosis due to the deposition of calcium-containing crystals in affected joints. We have documented the disease in an Argentinean kindred of northern Italian ancestry and in a French kindred from the Alsace region. Both families presented with a common phenotype including early age at onset and deposition of crystals of calcium pyrophosphate dihydrate in a similar pattern of affected joints. Affected family members were karyotypically normal. Linkage to the short arm of chromosome 5 was observed, consistent with a previous report of linkage of the CPPDD phenotype in a large British kindred to the 5p15 region. However, recombinants in the Argentinean kindred have enabled us to designate a region<1 cM in length between the markers D5S416 and D5S2114 as the CPPDD locus.[1]


  1. Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease. Andrew, L.J., Brancolini, V., de la Pena, L.S., Devoto, M., Caeiro, F., Marchegiani, R., Reginato, A., Gaucher, A., Netter, P., Gillet, P., Loeuille, D., Prockop, D.J., Carr, A., Wordsworth, B.F., Lathrop, M., Butcher, S., Considine, E., Everts, K., Nicod, A., Walsh, S., Williams, C.J. Am. J. Hum. Genet. (1999) [Pubmed]
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