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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Pseudomonas aeruginosa keratitis in knockout mice deficient in intercellular adhesion molecule 1.

In this study, the role of intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of Pseudomonas aeruginosa keratitis was examined by using inbred ICAM-1-deficient knockout mice. These mice had significantly less (P </= 0.02) ocular disease than wild-type mice, suggesting that ICAM-1 contributes to a more severe disease response following P. aeruginosa infection.[1]

References

  1. Pseudomonas aeruginosa keratitis in knockout mice deficient in intercellular adhesion molecule 1. Hobden, J.A., Masinick-McClellan, S., Barrett, R.P., Bark, K.S., Hazlett, L.D. Infect. Immun. (1999) [Pubmed]
 
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