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Gene Review

Icam1  -  intercellular adhesion molecule 1

Mus musculus

Synonyms: CD54, ICAM-1, Icam-1, Intercellular adhesion molecule 1, Ly-47, ...
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Disease relevance of Icam1


Psychiatry related information on Icam1


High impact information on Icam1


Chemical compound and disease context of Icam1


Biological context of Icam1


Anatomical context of Icam1


Associations of Icam1 with chemical compounds


Physical interactions of Icam1


Co-localisations of Icam1


Regulatory relationships of Icam1


Other interactions of Icam1


Analytical, diagnostic and therapeutic context of Icam1


  1. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. Xu, H., Gonzalo, J.A., St Pierre, Y., Williams, I.R., Kupper, T.S., Cotran, R.S., Springer, T.A., Gutierrez-Ramos, J.C. J. Exp. Med. (1994) [Pubmed]
  2. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. Johnson, L.A., Clasper, S., Holt, A.P., Lalor, P.F., Baban, D., Jackson, D.G. J. Exp. Med. (2006) [Pubmed]
  3. Expression of intercellular adhesion molecule-1 in murine hearts with acute myocarditis caused by coxsackievirus B3. Seko, Y., Matsuda, H., Kato, K., Hashimoto, Y., Yagita, H., Okumura, K., Yazaki, Y. J. Clin. Invest. (1993) [Pubmed]
  4. Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Matsushita, Y., Hasegawa, M., Matsushita, T., Fujimoto, M., Horikawa, M., Fujita, T., Kawasuji, A., Ogawa, F., Steeber, D.A., Tedder, T.F., Takehara, K., Sato, S. J. Immunol. (2007) [Pubmed]
  5. Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway. Moriyama, H., Yokono, K., Amano, K., Nagata, M., Hasegawa, Y., Okamoto, N., Tsukamoto, K., Miki, M., Yoneda, R., Yagi, N., Tominaga, Y., Kikutani, H., Hioki, K., Okumura, K., Yagita, H., Kasuga, M. J. Immunol. (1996) [Pubmed]
  6. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Gong, J., Chen, D., Kashiwaba, M., Kufe, D. Nat. Med. (1997) [Pubmed]
  7. Negative regulation of T-cell adhesion and activation by CD43. Manjunath, N., Correa, M., Ardman, M., Ardman, B. Nature (1995) [Pubmed]
  8. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Isobe, M., Yagita, H., Okumura, K., Ihara, A. Science (1992) [Pubmed]
  9. FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Victoratos, P., Lagnel, J., Tzima, S., Alimzhanov, M.B., Rajewsky, K., Pasparakis, M., Kollias, G. Immunity (2006) [Pubmed]
  10. The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Faria, A.M., Levay, A., Wang, Y., Kamphorst, A.O., Rosa, M.L., Nussenzveig, D.R., Balkan, W., Chook, Y.M., Levy, D.E., Fontoura, B.M. Immunity (2006) [Pubmed]
  11. Intercellular adhesion molecule 1 is the major adhesion molecule expressed during schistosome granuloma formation. Ritter, D.M., McKerrow, J.H. Infect. Immun. (1996) [Pubmed]
  12. Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis. Chaudhary, P., Marracci, G.H., Bourdette, D.N. J. Neuroimmunol. (2006) [Pubmed]
  13. Dietary fish oil enhances adhesion molecule and interleukin-6 expression in mice with polymicrobial sepsis. Hsu, C.S., Chiu, W.C., Yeh, C.L., Hou, Y.C., Chou, S.Y., Yeh, S.L. Br. J. Nutr. (2006) [Pubmed]
  14. Tumor-Necrosis-Factor-alpha-Gene-Deficient Mice Have Improved Cardiac Function Through Reduction of Intercellular Adhesion Molecule-1 in Myocardial Infarction. Sato, T., Suzuki, H., Shibata, M., Kusuyama, T., Omori, Y., Soda, T., Shoji, M., Iso, Y., Koba, S., Geshi, E., Katagiri, T., Shioda, S., Sekikawa, K. Circ. J. (2006) [Pubmed]
  15. Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1. Kornek, M., Raskopf, E., Guetgemann, I., Ocker, M., Gerceker, S., Gonzalez-Carmona, M.A., Rabe, C., Sauerbruch, T., Schmitz, V. J. Hepatol. (2006) [Pubmed]
  16. Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Klocke, R., Augustin, A., Ronsiek, M., Stief, A., van der Putten, H., Jockusch, H. Genomics (1997) [Pubmed]
  17. Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95. Wang, J., Lenardo, M.J. J. Exp. Med. (1997) [Pubmed]
  18. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. Collins, R.G., Velji, R., Guevara, N.V., Hicks, M.J., Chan, L., Beaudet, A.L. J. Exp. Med. (2000) [Pubmed]
  19. Molecular cloning of murine intercellular adhesion molecule (ICAM-1). Horley, K.J., Carpenito, C., Baker, B., Takei, F. EMBO J. (1989) [Pubmed]
  20. Effect of tumor necrosis factor alpha and intercellular adhesion molecule-1 expression on immunogenicity of murine liver cells in mice. Bumgardner, G.L., Li, J., Apte, S., Heininger, M., Frankel, W.L. Hepatology (1998) [Pubmed]
  21. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. Kunkel, E.J., Jung, U., Bullard, D.C., Norman, K.E., Wolitzky, B.A., Vestweber, D., Beaudet, A.L., Ley, K. J. Exp. Med. (1996) [Pubmed]
  22. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. Tang, Q., Hendricks, R.L. J. Exp. Med. (1996) [Pubmed]
  23. Critical amino acids in the lymphocyte function-associated antigen-1 I domain mediate intercellular adhesion molecule 3 binding and immune function. van Kooyk, Y., Binnerts, M.E., Edwards, C.P., Champe, M., Berman, P.W., Figdor, C.G., Bodary, S.C. J. Exp. Med. (1996) [Pubmed]
  24. Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma. Pati, S., Pelser, C.B., Dufraine, J., Bryant, J.L., Reitz, M.S., Weichold, F.F. Blood (2002) [Pubmed]
  25. Interferon-gamma is essential for the development of cerebral malaria. Rudin, W., Favre, N., Bordmann, G., Ryffel, B. Eur. J. Immunol. (1997) [Pubmed]
  26. Stimulation of P-selectin glycoprotein ligand-1 on mouse neutrophils activates beta 2-integrin mediated cell attachment to ICAM-1. Blanks, J.E., Moll, T., Eytner, R., Vestweber, D. Eur. J. Immunol. (1998) [Pubmed]
  27. Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway. Simon, S.I., Hu, Y., Vestweber, D., Smith, C.W. J. Immunol. (2000) [Pubmed]
  28. Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice. Saulnier, M., Huang, S., Aguet, M., Ryffel, B. Toxicology (1995) [Pubmed]
  29. Modulation of adhesion of lymphocytes to murine brain endothelial cells in vitro: relation to class II major histocompatibility complex expression. Goodall, C.A., Curtis, A.S., Lang, S.C. J. Neuroimmunol. (1992) [Pubmed]
  30. ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space. Basit, A., Reutershan, J., Morris, M.A., Solga, M., Rose, C.E., Ley, K. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  31. Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities. Stepkowski, S.M., Tu, Y., Condon, T.P., Bennett, C.F. J. Immunol. (1994) [Pubmed]
  32. Delayed expressed TNFR1 co-localize with ICAM-1 in astrocyte in mice brain after transient focal ischemia. Yin, L., Ohtaki, H., Nakamachi, T., Kudo, Y., Makino, R., Shioda, S. Neurosci. Lett. (2004) [Pubmed]
  33. Cytokine modulation of T-lymphocyte activation by intestinal smooth muscle cells. Hogaboam, C.M., Snider, D.P., Collins, S.M. Gastroenterology (1997) [Pubmed]
  34. Expression of adhesion molecules relevant to leukocyte migration on the microvilli of liver peritoneal mesothelial cells. Liang, Y., Sasaki, K. Anat. Rec. (2000) [Pubmed]
  35. Monoclonal antibodies targeting murine LFA-1 induce LFA-1/ICAM-1-independent homotypic lymphocyte aggregation. Wuthrich, R.P. Cell. Immunol. (1992) [Pubmed]
  36. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. Cybulsky, M.I., Iiyama, K., Li, H., Zhu, S., Chen, M., Iiyama, M., Davis, V., Gutierrez-Ramos, J.C., Connelly, P.W., Milstone, D.S. J. Clin. Invest. (2001) [Pubmed]
  37. ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Selzner, N., Selzner, M., Odermatt, B., Tian, Y., Van Rooijen, N., Clavien, P.A. Gastroenterology (2003) [Pubmed]
  38. Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. Lehmann, J.C., Jablonski-Westrich, D., Haubold, U., Gutierrez-Ramos, J.C., Springer, T., Hamann, A. J. Immunol. (2003) [Pubmed]
  39. The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development. Fine, J.S., Kruisbeek, A.M. J. Immunol. (1991) [Pubmed]
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