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Okayasu, R. et al.

Okayasu, Takahashi, Yamada, Hei, Ullrich,

Asbestos and DNA double strand breaks.

A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short-term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.[1]

References

Asbestos and DNA double strand breaks. Okayasu, R., Takahashi, S., Yamada, S., Hei, T.K., Ullrich, R.L. Cancer Res. (1999) [Pubmed]

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