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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Using hydroxylapatite ceramic buttons covered with periosteum to prevent cerebrospinal fluid leakage: technical note.

BACKGROUND: Many attempts have been made to prevent cerebrospinal fluid (CSF) leakage, but the procedures proposed to date are troublesome and not promising. We describe a method of completely preventing CSF leakage using hydroxylapatite ceramics. METHODS: Exposed frontal sinus, mastoid air cells, and frontal base defects caused by fracture are covered with periosteum or fascia and plugged with a trimmed hydroxylapatite ceramic button. RESULTS: There was no CSF leakage, postoperative meningitis, or other complication related to the technique in a consecutive series of 25 patients treated using this procedure. CONCLUSION: The use of this easy and quick technique may prevent CSF leakage completely.[1]


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