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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Fascia


Psychiatry related information on Fascia

  • Examination of 19 brains from patients with Alzheimer's disease showed approximately the same number of plaques in the stratum moleculare of the fascia dentata and in CA1 (Sommer's sector) of the hippocampus, even though the area of the latter is much greater [6].

High impact information on Fascia

  • However, at the fascia adherens junctional sites of cardiac muscle where vinculin is sharply confined, Sgp 130 was immunologically undetectable in both intact and EGTA-uncoupled tissue [7].
  • Near the intercalated disks, desmin labeling was intense within the interfibrillar spaces, but was completely segregated from the microfilament attachment sites (fascia adherens) where vinculin and alpha-actinin were localized [8].
  • Fixation and immunolabeling procedures were developed that permitted maximal retention of the two proteins at their natural sites as well as their adequate labeling. alpha-Actinin was found both on the Z-bands, as expected, and near the fascia adherens of the intercalated discs, whereas vinculin was confined to the latter sites [9].
  • Expression of the gap junction protein connexin43 (Cx43) and the fascia adherens junction protein N-cadherin was measured immunohistochemically in the same preparations [10].
  • At normal [K+], aspartate-like and glutamate-like immunoreactivities were colocalized in nerve terminals forming asymmetrical synapses on spines in stratum radiatum of CA1 and the inner molecular layer of fascia dentata (i.e., excitatory afferents from CA3 and hilus, respectively) [11].

Chemical compound and disease context of Fascia


Biological context of Fascia

  • The extent of LTP "saturation" in fascia dentata produced by the standard chronic LTP stimulation protocol was assessed both electrophysiologically and through the use of an anatomical marker (activation of the immediate-early gene zif268) [17].
  • RESULTS: Compared with autopsy cases, hippocampi from children with frequent seizures showed (a) decreased fascia dentata granule cell densities; (b) decreased PSA NCAM IR cell densities in the stratum granulosum, infragranular, and hilar regions; (c) no positive TUNEL-stained cells; and (d) aberrant supragranular mossy fiber axon connections [18].
  • These results suggest that kindling epileptogenesis is accompanied by an increased number and enhanced sensitivity of the expressed AMPA type glutamate receptors in the fascia dentata, leading to an enhanced excitatory synaptic transmission which may contribute to the process of kindling epileptogenesis [19].
  • Post-translational modifications included a very elevated hydroxylysine content, an increase in the total number of reducible cross-links, and the appearance of hydroxylysinohydroxynorleucine (virtually absent from normal palmar fascia) as the major reducible cross-link [20].
  • We have analysed the ultrastructure of the fascia surrounding the hernial lesions, the proline and lysine hydroxylation in the tissue, the type I-type III collagen ratio and the presence of metalloproteinases [21].

Anatomical context of Fascia


Associations of Fascia with chemical compounds

  • Within fascia dentata, GABA receptor binding was increased to an equivalent extent in stratum granulosum and throughout stratum moleculare; no increase was found in dentate hilus or stratum lacunosummoleculare or stratum radiatum of CA1 [27].
  • Somatostatin/GABA-immunoreactive neurons were localized mainly in the stratum oriens and in the hilus of the fascia dentata [28].
  • Unexpectedly, GABA receptor-mediated enhancement of benzodiazepine receptor binding was slightly attenuated in fascia dentata of kindled compared to control rats [27].
  • Like in vivo, entorhinal fibers, labeled by anterograde tracing with biocytin, terminate in the outer molecular layer of the fascia dentata [29].
  • Two glycoproteins corresponding to minor polypeptides visualized by Coomassie Blue staining were present in the fascia adherentes fraction [30].

Gene context of Fascia


Analytical, diagnostic and therapeutic context of Fascia


  1. Fibroblasts from the transversalis fascia of young patients with direct inguinal hernias show constitutive MMP-2 overexpression. Bellón, J.M., Bajo, A., Ga-Honduvilla, N., Gimeno, M.J., Pascual, G., Guerrero, A., Buján, J. Ann. Surg. (2001) [Pubmed]
  2. Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines. Bacher, A., Griebl, K., Mackamul, S., Mitreiter, R., Mückter, H., Ben-Shaul, Y. Exp. Cell Res. (1992) [Pubmed]
  3. Co-localization of somatostatin mRNA and parvalbumin in the dorsal rat hippocampus after cerebral ischemia. Bering, R., Diemer, N.H., Draguhn, A., Johansen, F.F. Hippocampus. (1995) [Pubmed]
  4. Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy. Mathern, G.W., Pretorius, J.K., Mendoza, D., Lozada, A., Kornblum, H.I. J. Neurosci. Res. (1998) [Pubmed]
  5. Neuromuscular manifestations of L-tryptophan-associated eosinophilia-myalgia syndrome: a histomorphologic analysis of 14 patients. Verity, M.A., Bulpitt, K.J., Paulus, H.E. Hum. Pathol. (1991) [Pubmed]
  6. The laminar distribution of neuritic plaques in the fascia dentata of patients with Alzheimer's disease. Crain, B.J., Burger, P.C. Acta Neuropathol. (1988) [Pubmed]
  7. A plasma membrane integral sialoglycoprotein (Sgp 130) molecularly distinguishes nonjunctional dense plaque sites of microfilament attachment. Rogalski, A.A. J. Cell Biol. (1987) [Pubmed]
  8. Immunoelectron microscopic studies of desmin (skeletin) localization and intermediate filament organization in chicken cardiac muscle. Tokuyasu, K.T., Dutton, A.H., Singer, S.J. J. Cell Biol. (1983) [Pubmed]
  9. Ultrastructure of chicken cardiac muscle as studied by double immunolabeling in electron microscopy. Tokuyasu, K.T., Dutton, A.H., Geiger, B., Singer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  10. Pulsatile stretch remodels cell-to-cell communication in cultured myocytes. Zhuang, J., Yamada, K.A., Saffitz, J.E., Kléber, A.G. Circ. Res. (2000) [Pubmed]
  11. Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus. Gundersen, V., Chaudhry, F.A., Bjaalie, J.G., Fonnum, F., Ottersen, O.P., Storm-Mathisen, J. J. Neurosci. (1998) [Pubmed]
  12. Pathology of local anesthetic-induced nerve injury. Kalichman, M.W., Powell, H.C., Myers, R.R. Acta Neuropathol. (1988) [Pubmed]
  13. A prospective randomized trial using solvent dehydrated fascia lata for the prevention of recurrent anterior vaginal wall prolapse. Gandhi, S., Goldberg, R.P., Kwon, C., Koduri, S., Beaumont, J.L., Abramov, Y., Sand, P.K. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  14. Subcutaneous sclerosis with fasciitis and eosinophilia after phytonadione injections. Janin-Mercier, A., Mosser, C., Souteyrand, P., Bourges, M. Archives of dermatology. (1985) [Pubmed]
  15. Drug resistance and P-glycoprotein expression in endothelial cells of newly formed capillaries induced by tumors. Iwahana, M., Utoguchi, N., Mayumi, T., Goryo, M., Okada, K. Anticancer Res. (1998) [Pubmed]
  16. The gluteal compartment syndrome. Hill, S.L., Bianchi, J. The American surgeon. (1997) [Pubmed]
  17. LTP saturation and spatial learning disruption: effects of task variables and saturation levels. Barnes, C.A., Jung, M.W., McNaughton, B.L., Korol, D.L., Andreasson, K., Worley, P.F. J. Neurosci. (1994) [Pubmed]
  18. Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata. Mathern, G.W., Leiphart, J.L., De Vera, A., Adelson, P.D., Seki, T., Neder, L., Leite, J.P. Epilepsia (2002) [Pubmed]
  19. Rat hippocampal kindling induces changes in the glutamate receptor mRNA expression patterns in dentate granule neurons. Kamphuis, W., De Rijk, T.C., Talamini, L.M., Lopes da Silva, F.H. Eur. J. Neurosci. (1994) [Pubmed]
  20. Biochemical changes in the collagen of the palmar fascia in patients with Dupuytren's disease. Brickley-Parsons, D., Glimcher, M.J., Smith, R.J., Albin, R., Adams, J.P. The Journal of bone and joint surgery. American volume. (1981) [Pubmed]
  21. Study of biochemical substrate and role of metalloproteinases in fascia transversalis from hernial processes. Bellón, J.M., Buján, J., Honduvilla, N.G., Jurado, F., Gimeno, M.J., Turnay, J., Olmo, N., Lizarbe, M.A. Eur. J. Clin. Invest. (1997) [Pubmed]
  22. Amyloid deposits in bioprosthetic cardiac valves after long-term implantation in man. A new localization of amyloidosis. Goffin, Y.A., Gruys, E., Sorenson, G.D., Wellens, F. Am. J. Pathol. (1984) [Pubmed]
  23. Somatostatin- and neuropeptide Y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy. Sundstrom, L.E., Brana, C., Gatherer, M., Mepham, J., Rougier, A. Brain (2001) [Pubmed]
  24. One-stage reconstruction of large midline abdominal wall defects using a composite free anterolateral thigh flap with vascularized fascia lata. Kuo, Y.R., Kuo, M.H., Lutz, B.S., Huang, Y.C., Liu, Y.T., Wu, S.C., Hsieh, K.C., Hsien, C.H., Jeng, S.F. Ann. Surg. (2004) [Pubmed]
  25. Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro. Varallo, V.M., Gan, B.S., Seney, S., Ross, D.C., Roth, J.H., Richards, R.S., McFarlane, R.M., Alman, B., Howard, J.C. Oncogene (2003) [Pubmed]
  26. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Mathern, G.W., Mendoza, D., Lozada, A., Pretorius, J.K., Dehnes, Y., Danbolt, N.C., Nelson, N., Leite, J.P., Chimelli, L., Born, D.E., Sakamoto, A.C., Assirati, J.A., Fried, I., Peacock, W.J., Ojemann, G.A., Adelson, P.D. Neurology (1999) [Pubmed]
  27. gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. Shin, C., Pedersen, H.B., McNamara, J.O. J. Neurosci. (1985) [Pubmed]
  28. Different populations of GABAergic neurons in the visual cortex and hippocampus of cat contain somatostatin- or cholecystokinin-immunoreactive material. Somogyi, P., Hodgson, A.J., Smith, A.D., Nunzi, M.G., Gorio, A., Wu, J.Y. J. Neurosci. (1984) [Pubmed]
  29. Role of afferent innervation and neuronal activity in dendritic development and spine maturation of fascia dentata granule cells. Frotscher, M., Drakew, A., Heimrich, B. Cereb. Cortex (2000) [Pubmed]
  30. A biochemical dissection of the cardiac intercalated disk: isolation of subcellular fractions containing fascia adherentes and gap junctions. Colaco, C.A., Evans, W.H. J. Cell. Sci. (1981) [Pubmed]
  31. Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. Mathern, G.W., Babb, T.L., Pretorius, J.K., Leite, J.P. J. Neurosci. (1995) [Pubmed]
  32. Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata. Quartu, M., Serra, M.P., Manca, A., Mascia, F., Follesa, P., Del Fiacco, M. Brain Res. (2005) [Pubmed]
  33. Alterations in the extracellular matrix proteoglycan profile in Dupuytren's contracture affect the palmar fascia. Koźma, E.M., Olczyk, K., Wisowski, G., Głowacki, A., Bobiński, R. J. Biochem. (2005) [Pubmed]
  34. Estrogen, progesterone, and androgen receptor expression in levator ani muscle and fascia. Copas, P., Bukovsky, A., Asbury, B., Elder, R.F., Caudle, M.R. Journal of women's health & gender-based medicine. (2001) [Pubmed]
  35. Prospective evaluation of vacuum-assisted fascial closure after open abdomen: planned ventral hernia rate is substantially reduced. Miller, P.R., Meredith, J.W., Johnson, J.C., Chang, M.C. Ann. Surg. (2004) [Pubmed]
  36. Sustained potential shifts and paroxysmal discharges in hippocampal formation. Somjen, G.G., Aitken, P.G., Giacchino, J.L., McNamara, J.O. J. Neurophysiol. (1985) [Pubmed]
  37. GABAergic innervation of the rat fascia dentata: a novel type of interneuron in the granule cell layer with extensive axonal arborization in the molecular layer. Soriano, E., Frotscher, M. J. Comp. Neurol. (1993) [Pubmed]
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