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Chemical Compound Review

piperaquine     7-chloro-4-[4-[3-[4-(7- chloroquinolin-4...

Synonyms: PubChem15392, SureCN131649, AKOS015896173, FT-0650576, BRN 0905079, ...
 
 
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Disease relevance of Piperaquinoline

  • CONCLUSIONS: The current dosage of DP (6.4 mg/kg DHA and 51.2 mg/kg piperaquine phosphate) given over the course of 48 h is highly effective, safe, and well tolerated for the treatment of multidrug-resistant falciparum malaria, and its efficacy is not improved by the addition of more DHA [1].
  • METHODS: The disposition of piperaquine was studied in 85 Cambodian patients with uncomplicated falciparum or vivax malaria treated with the piperaquine-dihydroartemisinin coformulation Artekin [2].
  • The combination of dihydroartemisinin (DHA) and piperaquine (PQP) in the form of Artekin has been developed as an alternative to established combinations, such as artesunate-mefloquine, primarily to reduce treatment costs and toxicity [3].
 

High impact information on Piperaquinoline

 

Chemical compound and disease context of Piperaquinoline

 

Biological context of Piperaquinoline

 

Anatomical context of Piperaquinoline

  • Malarial pigments were deposited in many organs or phagocytized by macrophages in 1 monkey (No. 131), it was cured by piperaquine phosphate but died of trauma and necrosis of the fore limb; cellular atrophy and disappearance of pancreatic islets, parathyroid and pituitary cells were also observed [9].
 

Analytical, diagnostic and therapeutic context of Piperaquinoline

References

  1. Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand. Ashley, E.A., Krudsood, S., Phaiphun, L., Srivilairit, S., McGready, R., Leowattana, W., Hutagalung, R., Wilairatana, P., Brockman, A., Looareesuwan, S., Nosten, F., White, N.J. J. Infect. Dis. (2004) [Pubmed]
  2. Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria. Hung, T.Y., Davis, T.M., Ilett, K.F., Karunajeewa, H., Hewitt, S., Denis, M.B., Lim, C., Socheat, D. British journal of clinical pharmacology. (2004) [Pubmed]
  3. An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria. Tangpukdee, N., Krudsood, S., Thanachartwet, W., Chalermrut, K., Pengruksa, C., Srivilairit, S., Silachamroon, U., Wilairatana, P., Phongtananant, S., Kano, S., Looareesuwan, S. Southeast Asian J. Trop. Med. Public Health (2005) [Pubmed]
  4. Effects of a high-fat meal on the relative oral bioavailability of piperaquine. Sim, I.K., Davis, T.M., Ilett, K.F. Antimicrob. Agents Chemother. (2005) [Pubmed]
  5. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. Vennerstrom, J.L., Ellis, W.Y., Ager, A.L., Andersen, S.L., Gerena, L., Milhous, W.K. J. Med. Chem. (1992) [Pubmed]
  6. Characterization of human urinary metabolites of the antimalarial piperaquine. Tarning, J., Bergqvist, Y., Day, N.P., Bergquist, J., Arvidsson, B., White, N.J., Ashton, M., Lindeg??rdh, N. Drug Metab. Dispos. (2006) [Pubmed]
  7. CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam. Giao, P.T., de Vries, P.J., Hung, l.e. .Q., Binh, T.Q., Nam, N.V., Kager, P.A. Trop. Med. Int. Health (2004) [Pubmed]
  8. Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria. Karunajeewa, H., Lim, C., Hung, T.Y., Ilett, K.F., Denis, M.B., Socheat, D., Davis, T.M. British journal of clinical pharmacology. (2004) [Pubmed]
  9. Histopathological changes of Macaca mulatta infected with Plasmodium knowlesi. Chen, L., Li, G., Lu, Y., Luo, Z. Chin. Med. J. (2001) [Pubmed]
  10. Automated solid-phase extraction method for the determination of piperaquine in whole blood by rapid liquid chromatography. Lindegårdh, N., Ashton, M., Bergqvist, Y. Therapeutic drug monitoring. (2003) [Pubmed]
  11. Characterization and quantitative determination of impurities in piperaquine phosphate by HPLC and LC/MS/MS. Dongre, V.G., Karmuse, P.P., Ghugare, P.D., Gupta, M., Nerurkar, B., Shaha, C., Kumar, A. Journal of pharmaceutical and biomedical analysis (2007) [Pubmed]
  12. Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male subjects. Röshammar, D., Hai, T.N., Friberg Hietala, S., Van Huong, N., Ashton, M. Eur. J. Clin. Pharmacol. (2006) [Pubmed]
 
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