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Chemical Compound Review

Imaquinone     3-[[(1R,2S,4aS,8aS)-1,2,4a- trimethyl-5...

Synonyms: ilimaquinone, Illimaquinone, CHEMBL155085, SureCN517890, CHEBI:70133, ...
 
 
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Gene context of AIDS001905

  • Thus, among the tested connexins, ilimaquinone has a strong specificity for connexin43, and the mechanism appears independent of the Golgi complex and of protein kinase C [12].
  • A GRF2 mutant missing the IQ sequence was competent for Ras activation but failed to couple this to stimulation of the ERK pathway [14].
  • Ilimaquinone (IQ) is a sea sponge metabolite which induces the complete vesiculation of the Golgi apparatus and we show here that the addition of IQ to MDCK cells also results in the disruption of the AMF-R tubule [10].
  • Illimaquinone inhibited the RNase H activity of the enzyme at concentrations of 5 to 10 microgram/ml, whereas RNA-dependent DNA polymerase and DNA-dependent DNA polymerase activities were considerably less susceptible to this inhibition [2].

References

  1. The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses. Loya, S., Hizi, A. J. Biol. Chem. (1993) [Pubmed]
  2. Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase. Loya, S., Tal, R., Kashman, Y., Hizi, A. Antimicrob. Agents Chemother. (1990) [Pubmed]
  3. Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Lu, P.H., Chueh, S.C., Kung, F.L., Pan, S.L., Shen, Y.C., Guh, J.H. Eur. J. Pharmacol. (2007) [Pubmed]
  4. Regulation of Golgi structure through heterotrimeric G proteins. Jamora, C., Takizawa, P.A., Zaarour, R.F., Denesvre, C., Faulkner, D.J., Malhotra, V. Cell (1997) [Pubmed]
  5. Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone. Takizawa, P.A., Yucel, J.K., Veit, B., Faulkner, D.J., Deerinck, T., Soto, G., Ellisman, M., Malhotra, V. Cell (1993) [Pubmed]
  6. Functional specialization of stable and dynamic microtubules in protein traffic in WIF-B cells. Poüs, C., Chabin, K., Drechou, A., Barbot, L., Phung-Koskas, T., Settegrana, C., Bourguet-Kondracki, M.L., Maurice, M., Cassio, D., Guyot, M., Durand, G. J. Cell Biol. (1998) [Pubmed]
  7. Reconstitution of vesiculated Golgi membranes into stacks of cisternae: requirement of NSF in stack formation. Acharya, U., McCaffery, J.M., Jacobs, R., Malhotra, V. J. Cell Biol. (1995) [Pubmed]
  8. Microtubule independent vesiculation of Golgi membranes and the reassembly of vesicles into Golgi stacks. Veit, B., Yucel, J.K., Malhotra, V. J. Cell Biol. (1993) [Pubmed]
  9. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Anborgh, P.H., Qian, X., Papageorge, A.G., Vass, W.C., DeClue, J.E., Lowy, D.R. Mol. Cell. Biol. (1999) [Pubmed]
  10. The AMF-R tubule is a smooth ilimaquinone-sensitive subdomain of the endoplasmic reticulum. Wang, H.J., Benlimame, N., Nabi, I. J. Cell. Sci. (1997) [Pubmed]
  11. Ilimaquinone inhibits the cytotoxicities of ricin, diphtheria toxin, and other protein toxins in Vero cells. Nambiar, M.P., Wu, H.C. Exp. Cell Res. (1995) [Pubmed]
  12. Ilimaquinone inhibits gap junctional communication in a connexin isotype-specific manner. Cruciani, V., Mikalsen, S.O. Exp. Cell Res. (2005) [Pubmed]
  13. Loss of gap junction plaques and inhibition of intercellular communication in ilimaquinone-treated BICR-M1Rk and NRK cells. Feldman, P.A., Kim, J., Laird, D.W. J. Membr. Biol. (1997) [Pubmed]
  14. Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2. de Hoog, C.L., Fan, W.T., Goldstein, M.D., Moran, M.F., Koch, C.A. Mol. Cell. Biol. (2000) [Pubmed]
  15. Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi. Cortes-Bratti, X., Chaves-Olarte, E., Lagergård, T., Thelestam, M. Infect. Immun. (2000) [Pubmed]
  16. S-adenosylmethionine reverses ilimaquinone's vesiculation of the Golgi apparatus: a fluorescence study on the cellular interactions of ilimaquinone. Casaubon, R.L., Snapper, M.L. Bioorg. Med. Chem. Lett. (2001) [Pubmed]
  17. Photoaffinity study of the cellular interactions of ilimaquinone. Radeke, H.S., Snapper, M.L. Bioorg. Med. Chem. (1998) [Pubmed]
  18. Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel. Nakamura, M., Nakazawa, J., Usui, T., Osada, H., Kono, Y., Takatsuki, A. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
 
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