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Gene Review

ZNF197  -  zinc finger protein 197

Homo sapiens

Synonyms: D3S1363E, P18, VHLaK, ZKSCAN9, ZNF166, ...
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Disease relevance of ZNF197

  • The ZnF20 mRNA was overexpressed in three of six thyroid papillary carcinomas as compared with paired normal thyroid tissue controls [1].
  • We examined the relationship between HIV-specific CTL activity and the profile of cytokine production induced by mAb to CD3 and HIV envelope (env) peptides P18 and T1 in PBMC derived from 0.6- to 3.6-yr-old children with perinatal HIV infection [2].
  • An HIV-1 envelope peptide, DNA plasmid, and recombinant modified vaccinia virus Ankara (rMVA) expressing the H-2D(d)-restricted cytotoxic T lymphocyte P18 epitope were used as immunogens to test for their ability to prime and boost anti-HIV-1 T-cell responses at mucosal and systemic sites in BALB/c mice [3].
  • The enzyme has been purified to homogeneity from Nocardia sp. strain P18 [4].
  • Therefore, sequence analysis would predict that the murine rotaviruses are G3 or G3-like and represent at least two unique P types (tentatively P17 for EW, EB, EC, and EL and P18 for EHP) [5].

High impact information on ZNF197

  • We demonstrate that the KRAB-A domain in VHLaK mediates pVHL binding and functions as a transcriptional repression module [6].
  • In this study, we examined the contribution of the cell cycle inhibitor genes P15, P16, and P18 to pathogenesis in a large panel of 209 cytogenetically characterized B-cell NHL tumors representing varied histologic groups [7].
  • In this study, we have evaluated the effect of a substitution outside the reactive site loop (P18) or in the reactive site loop (P6 and P10) on proteinase specificity and conformational transitions in PAI-1 [8].
  • Responses to PHA, HLA alloantigens, HIV envelope peptides T1 and P18, and tetanus toxoid were studied in PBMC derived from asymptomatic and mildly symptomatic HIV-infected children [9].
  • A peptide, LRRSSGASGLLTSEHHSR (P18), corresponding to the amino acid sequence Leu423-Arg440 in the putative regulatory domain of the rat adipocyte cGI-PDE was synthesized [10].

Chemical compound and disease context of ZNF197

  • After nicotine withdrawal, WGD returned to control level within 1 day, whereas total body weight recovered by P18 [11].
  • Lymphoproliferative response to synthetic V3 loop P18 peptide and HIV-1 envelope glycoprotein among individuals immunized with gp160 candidate vaccines [12].

Biological context of ZNF197

  • Using this fragment to probe a cDNA library, a full-length cDNA (ZnF20) was isolated that was 4333 bp in length and contained an open reading frame of 1029 amino acids [1].
  • Sequencing and comparisons of genomes of P6, P12, P18 and P22 showed that mutational numbers in genomes of different passages increased with adaptive passages, and mutations scattered over the genome [13].
  • Despite the low immunization dose of single peptides (10 micrograms) present in the mixture of peptides collectively linked to the carriers, antibody responses to most of the individual peptides were high (dilution endpoints 1: greater than 16,000, 1: greater than 80,000 for the nef and gag P18 conjugates, respectively) [14].
  • Three slow wave components, P10, N13 and P18, can be seen in the cervical somatosensory evoked potential (CSEP) in response to median nerve stimulation recorded by an electrode in the epidural space at the dorsal aspect of the cervical spinal cord referenced to an electrode at the suprasternal notch [15].

Anatomical context of ZNF197

  • The identity of this E protein with leukocyte Ag CD59 (P18, HRF20) was confirmed immunochemically and by N-terminal amino acid sequence analysis [16].
  • Neurons in the dorsal lateral geniculate nucleus (dLGN) and superior colliculus (SC) were generated at P1-P10 and P1-P18 respectively [17].
  • Moreover, the cytotoxic T cell response elicited by immunization with a mixture of cluster peptide-P18MN vaccine constructs was at least as cross-reactive against known viral variant P18 target sequences as a CTL line produced by immunization with a vaccinia construct expressing recombinant gp160 MN [18].
  • These results suggest that P36 and P18 antigens located in different compartments of the sperm head may participate in the sperm-oolemma interaction [19].
  • P18 (KWKLFKKIPKFLHLAKKF-NH2) is an antimicrobial peptide designed from a cecropin A-magainin 2 hybrid that has potent antibacterial activity without hemolytic activity against human erythrocytes [20].

Associations of ZNF197 with chemical compounds

  • The ZnF20 cDNA hybridized to multiple transcripts in a thyroid cancer cell line (8.0, 4.5 and 2 kb) that increased after cycloheximide treatment and decayed <2 h after addition of actinomycin D [1].
  • Similar radiosequencing profiles indicated that the second most N-terminal serine, corresponding to Ser-427 in the intact cGI-PDE, was phosphorylated by cAMP-PK in both P18 and authentic cGI-PDE [10].
  • Five groups were established based upon post-natal age (P) at exposure to cisplatin, P10 (n = 8), P14 (n = 8), P18 (n = 6), P22 (n = 7) and P42 (n = 7) [21].

Analytical, diagnostic and therapeutic context of ZNF197

  • The fraction could be further resolved into eighteen peaks designated P1-P18 by HPLC on a Protein Pak SP 5PW column that was eluted with a linear gradient of 0.1-0.6 M CH3COONa in 20 mM NaH2PO4-Na2HPO4 at pH 7.4 P3-P18 were demonstrated to be isotoxins of the beta-bungarotoxin family [22].
  • An ELISA using recombinant P18 and P39 as antigens was 91.9% sensitive and 99.0% specific, with positive and negative predictive values of 97.1% and 97.0%, respectively, comparing favourably with the 27.0% sensitivity of a routinely used serological assay [23].


  1. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Gonsky, R., Knauf, J.A., Elisei, R., Wang, J.W., Su, S., Fagin, J.A. Nucleic Acids Res. (1997) [Pubmed]
  2. Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection. Wasik, T.J., Jagodzinski, P.P., Hyjek, E.M., Wustner, J., Trinchieri, G., Lischner, H.W., Kozbor, D. J. Immunol. (1997) [Pubmed]
  3. Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. Peacock, J.W., Nordone, S.K., Jackson, S.S., Liao, H.X., Letvin, N.L., Yafal, A.G., Gritz, L., Mazzara, G.P., Haynes, B.F., Staats, H.F. J. Virol. (2004) [Pubmed]
  4. Purification and properties of alpha-pinene oxide lyase from Nocardia sp. strain P18.3. Griffiths, E.T., Harries, P.C., Jeffcoat, R., Trudgill, P.W. J. Bacteriol. (1987) [Pubmed]
  5. Comparison of VP4 and VP7 of five murine rotavirus strains. Dunn, S.J., Burns, J.W., Cross, T.L., Vo, P.T., Ward, R.L., Bremont, M., Greenberg, H.B. Virology (1994) [Pubmed]
  6. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. Li, Z., Wang, D., Na, X., Schoen, S.R., Messing, E.M., Wu, G. EMBO J. (2003) [Pubmed]
  7. Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma. Koduru, P.R., Zariwala, M., Soni, M., Gong, J.Z., Xiong, Y., Broome, J.D. Blood (1995) [Pubmed]
  8. Proteinase specificity and functional diversity in point mutants of plasminogen activator inhibitor 1. Gils, A., Declerck, P.J. J. Biol. Chem. (1997) [Pubmed]
  9. Cytokine patterns during progression to AIDS in children with perinatal HIV infection. Hyjek, E., Lischner, H.W., Hyslop, T., Bartkowiak, J., Kubin, M., Trinchieri, G., Kozbor, D. J. Immunol. (1995) [Pubmed]
  10. Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase. Rascón, A., Degerman, E., Taira, M., Meacci, E., Smith, C.J., Manganiello, V., Belfrage, P., Tornqvist, H. J. Biol. Chem. (1994) [Pubmed]
  11. Chronic nicotine induces growth retardation in neonatal rat pups. Huang, L.Z., Hsiao, S.H., Trzeciakowski, J., Frye, G.D., Winzer-Serhan, U.H. Life Sci. (2006) [Pubmed]
  12. Lymphoproliferative response to synthetic V3 loop P18 peptide and HIV-1 envelope glycoprotein among individuals immunized with gp160 candidate vaccines. Moukrim, Z., Cho, Y.Y., Mbika, J.P., Achour, A. Biomed. Pharmacother. (1996) [Pubmed]
  13. Mutational characteristics in consecutive passage of rapidly replicating variants of hepatitis A virus strain H2 during cell culture adaptation. Hu, N.Z., Hu, Y.Z., Shi, H.J., Liu, G.D., Qu, S. World J. Gastroenterol. (2002) [Pubmed]
  14. Confronting the hypervariability of an immunodominant epitope eliciting virus neutralizing antibodies from the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1)--II. Synthetic peptides linked to HIV-1 carrier proteins gag and nef. Neurath, A.R., Strick, N., Kolbe, H., Kieny, M.P., Girard, M., Jiang, S. Mol. Immunol. (1991) [Pubmed]
  15. Epidurally recorded cervical somatosensory evoked potential in humans. Berić, A., Dimitrijević, M.R., Prevec, T.S., Sherwood, A.M. Electroencephalography and clinical neurophysiology. (1986) [Pubmed]
  16. The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9. Rollins, S.A., Sims, P.J. J. Immunol. (1990) [Pubmed]
  17. Generation and death of cells in the dorsal lateral geniculate nucleus and superior colliculus of the wallaby, Setonix brachyurus (quokka). Harman, A.M. J. Comp. Neurol. (1991) [Pubmed]
  18. Candidate HIV type 1 multideterminant cluster peptide-P18MN vaccine constructs elicit type 1 helper T cells, cytotoxic T cells, and neutralizing antibody, all using the same adjuvant immunization. Ahlers, J.D., Dunlop, N., Pendleton, C.D., Newman, M., Nara, P.L., Berzofsky, J.A. AIDS Res. Hum. Retroviruses (1996) [Pubmed]
  19. Isolation and characterisation of two sperm membrane proteins recognised by sperm-associated antibodies in infertile men. Auer, J., Senechal, H., Desvaux, F.X., Albert, M., De Almeida, M. Mol. Reprod. Dev. (2000) [Pubmed]
  20. Structure and fungicidal activity of a synthetic antimicrobial peptide, P18, and its truncated peptides. Lee, D.G., Hahm, K.S., Shin, S.Y. Biotechnol. Lett. (2004) [Pubmed]
  21. Age-related sensitivity to cisplatin ototoxicity in gerbils. Sie, K.C., deSerres, L.M., Norton, S.J. Hear. Res. (1999) [Pubmed]
  22. Resolution of isotoxins in the beta-bungarotoxin family. Chu, C.C., Li, S.H., Chen, Y.H. Journal of chromatography. A. (1995) [Pubmed]
  23. Improved serodiagnosis of Campylobacter jejuni infections using recombinant antigens. Schmidt-Ott, R., Brass, F., Scholz, C., Werner, C., Gross, U. J. Med. Microbiol. (2005) [Pubmed]
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