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Gene Review

B4galnt2  -  beta-1,4-N-acetyl-galactosaminyl...

Mus musculus

Synonyms: AI593864, Beta-1,4 N-acetylgalactosaminyltransferase 2, Dlb-1, Dlb1, Galg2, ...
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Disease relevance of B4galnt2


High impact information on B4galnt2


Biological context of B4galnt2


Anatomical context of B4galnt2

  • Following treatment with PhIP, there was no difference in the number of Dlb-1 locus mutations between the proximal and distal ends of the small intestine in uninduced animals, indicating that the bile duct is unlikely to be responsible for transport of mutation inducing metabolites of PhIP to the small intestine [10].
  • Previous studies have shown that although this compound produces multiple tumors in the colons in most individuals of every species tested, it is, at best, marginally mutagenic in the bone marrow (micronuclei) and small intestine (Dlb-1 mutations) [11].
  • Chromosome aberrations induced in lymphocytes and Dlb-1 mutations induced in the small intestine were measured after daily doses of 0.64, 1.85 or 5.5 cGy 137Cs gamma rays administered for 21, 42 or 63 days [12].
  • The lacI assay (Big Blue Mouse assay) is not as sensitive to some types of mutation as is Dlb-1 but was used in the colonic epithelium [13].

Associations of B4galnt2 with chemical compounds

  • Chronic administration of 1,2-dimethylhydrazine (20 mg/kg/week s.c. for 10 weeks) induced Dlb-1 mutants, whereas administration of a single dose did not [14].
  • Similarly, chronic dimethylnitrosamine treatment p.o. (0.001% in drinking water for 8 weeks) induced Dlb-1 mutants, but acute administration did not [14].

Other interactions of B4galnt2

  • Studies in congenic Ahr-non-responsive versus Ahr-responsive mice indicated that induction of CYP1A1 was associated with increased numbers of Dlb-1 mutations [15].

Analytical, diagnostic and therapeutic context of B4galnt2


  1. Factors affecting somatic mutation frequencies in vivo. Zhang, X.B., Urlando, C., Tao, K.S., Heddle, J.A. Mutat. Res. (1995) [Pubmed]
  2. Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Mohlke, K.L., Purkayastha, A.A., Westrick, R.J., Smith, P.L., Petryniak, B., Lowe, J.B., Ginsburg, D. Cell (1999) [Pubmed]
  3. Clonal analysis of mouse intestinal epithelial progenitors. Bjerknes, M., Cheng, H. Gastroenterology (1999) [Pubmed]
  4. Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine. Toft, N.J., Winton, D.J., Kelly, J., Howard, L.A., Dekker, M., te Riele, H., Arends, M.J., Wyllie, A.H., Margison, G.P., Clarke, A.R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea. Shaver-Walker, P.M., Urlando, C., Tao, K.S., Zhang, X.B., Heddle, J.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. A TaqI restriction fragment length polymorphism at the Hox-2.1 locus cosegregates with the Dlb-1 locus on mouse chromosome 11. Mock, B., Hilgers, J., Huppi, K., D'Hoostelaere, L. Nucleic Acids Res. (1987) [Pubmed]
  7. Mutagenicity of methyl methanesulfonate (MMS) in vivo at the Dlb-1 native locus and a lacI transgene. Tao, K.S., Urlando, C., Heddle, J.A. Environ. Mol. Mutagen. (1993) [Pubmed]
  8. Characterization and mapping of DNA sequence homologous to mouse U1a1 snRNA: localization on chromosome 11 near the Dlb-1 and Re loci. Michael, S.K., Hilgers, J., Kozak, C., Whitney, J.B., Howard, E.F. Somat. Cell Mol. Genet. (1986) [Pubmed]
  9. Mouse models for induced genetic instability at endogenous loci. Reliene, R., Schiestl, R.H. Oncogene (2003) [Pubmed]
  10. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine. Brooks, R.A., Gooderham, N.J., Zhao, K., Edwards, R.J., Howard, L.A., Boobis, A.R., Winton, D.J. Cancer Res. (1994) [Pubmed]
  11. The potent colon carcinogen, 1,2-dimethylhydrazine induces mutations primarily in the colon. Newell, L.E., Heddle, J.A. Mutat. Res. (2004) [Pubmed]
  12. The accumulation of chromosome aberrations and Dlb-1 mutations in mice with highly fractionated exposure to gamma radiation. Tucker, J.D., Sorensen, K.J., Chu, C.S., Nelson, D.O., Ramsey, M.J., Urlando, C., Heddle, J.A. Mutat. Res. (1998) [Pubmed]
  13. Mutagenicity of high fat diets in the colon and small intestine of transgenic mice. Zhang, X.B., Tao, K., Urlando, C., Shaver-Walker, P., Heddle, J.A. Mutagenesis (1996) [Pubmed]
  14. Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Winton, D.J., Gooderham, N.J., Boobis, A.R., Davies, D.S., Ponder, B.A. Cancer Res. (1990) [Pubmed]
  15. The mutagenicity of benzo[a]pyrene in mouse small intestine. Brooks, R.A., Gooderham, N.J., Edwards, R.J., Boobis, A.R., Winton, D.J. Carcinogenesis (1999) [Pubmed]
  16. Somatic mutation in the mammary gland: influence of time and estrus. Sun, B., Shima, N., Heddle, J.A. Mutat. Res. (1999) [Pubmed]
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