Gene Review:
Irak1 - interleukin-1 receptor-associated kinase 1
Mus musculus
Synonyms:
AA408924, IRAK, IRAK-1, IRAK1-S, Il1rak, ...
- IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection. Verdrengh, M., Thomas, J.A., Hultgren, O.H. Microbes Infect. (2004)
- IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity. Deng, C., Radu, C., Diab, A., Tsen, M.F., Hussain, R., Cowdery, J.S., Racke, M.K., Thomas, J.A. J. Immunol. (2003)
- Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. Thomas, J.A., Allen, J.L., Tsen, M., Dubnicoff, T., Danao, J., Liao, X.C., Cao, Z., Wasserman, S.A. J. Immunol. (1999)
- IRAK-M is a negative regulator of Toll-like receptor signaling. Kobayashi, K., Hernandez, L.D., Galán, J.E., Janeway, C.A., Medzhitov, R., Flavell, R.A. Cell (2002)
- Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Suzuki, N., Suzuki, S., Duncan, G.S., Millar, D.G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, J.M., Wesche, H., Ohashi, P.S., Mak, T.W., Yeh, W.C. Nature (2002)
- IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. Li, H., Cuartas, E., Cui, W., Choi, Y., Crawford, T.D., Ke, H.Z., Kobayashi, K.S., Flavell, R.A., Vignery, A. J. Exp. Med. (2005)
- Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. Uematsu, S., Sato, S., Yamamoto, M., Hirotani, T., Kato, H., Takeshita, F., Matsuda, M., Coban, C., Ishii, K.J., Kawai, T., Takeuchi, O., Akira, S. J. Exp. Med. (2005)
- Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. Burns, K., Janssens, S., Brissoni, B., Olivos, N., Beyaert, R., Tschopp, J. J. Exp. Med. (2003)
- Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. Jurrmann, N., Brigelius-Flohé, R., Böl, G.F. J. Nutr. (2005)
- IRAK contributes to burn-triggered myocardial contractile dysfunction. Thomas, J.A., Tsen, M.F., White, D.J., Horton, J.W. Am. J. Physiol. Heart Circ. Physiol. (2002)
- Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance. Kim, J.A., Yeh, D.C., Ver, M., Li, Y., Carranza, A., Conrads, T.P., Veenstra, T.D., Harrington, M.A., Quon, M.J. J. Biol. Chem. (2005)
- A novel splice variant of mouse interleukin-1-receptor-associated kinase-1 (IRAK-1) activates nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK). Yanagisawa, K., Tago, K., Hayakawa, M., Ohki, M., Iwahana, H., Tominaga, S. Biochem. J. (2003)
- Interleukin-1 receptor-associated kinase gene Il1rak maps to the mouse X chromosome. Centanni, J.M., de Miguel, M., Gopalan, G., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Donovan, P.J. Mamm. Genome (1998)
- Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages. Xu, H., An, H., Yu, Y., Zhang, M., Qi, R., Cao, X. J. Biol. Chem. (2003)
- IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. Thomas, J.A., Haudek, S.B., Koroglu, T., Tsen, M.F., Bryant, D.D., White, D.J., Kusewitt, D.F., Horton, J.W., Giroir, B.P. Am. J. Physiol. Heart Circ. Physiol. (2003)
- Ethanol-induced sensitization to endotoxin in Kupffer cells is dependent upon oxidative stress. Yamashina, S., Takei, Y., Ikejima, K., Enomoto, N., Kitamura, T., Sato, N. Alcohol. Clin. Exp. Res. (2005)
- Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin. Moors, M.A., Li, L., Mizel, S.B. Infect. Immun. (2001)
- IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. Huang, Y., Li, T., Sane, D.C., Li, L. J. Biol. Chem. (2004)
- The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages. Taylor, A.W. J. Neuroimmunol. (2005)
- Developmental and tissue-specific expression of mouse pelle-like protein kinase. Trofimova, M., Sprenkle, A.B., Green, M., Sturgill, T.W., Goebl, M.G., Harrington, M.A. J. Biol. Chem. (1996)
- Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity. Böl, G.F., Jurrmann, N., Brigelius-Flohé, R. Biochem. Biophys. Res. Commun. (2005)
- IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. Swantek, J.L., Tsen, M.F., Cobb, M.H., Thomas, J.A. J. Immunol. (2000)
- Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice. Kanakaraj, P., Ngo, K., Wu, Y., Angulo, A., Ghazal, P., Harris, C.A., Siekierka, J.J., Peterson, P.A., Fung-Leung, W.P. J. Exp. Med. (1999)
- Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease. Hobbs, R.M., Watt, F.M. J. Biol. Chem. (2003)
- Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-kappaB-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding. Darieva, Z., Lasunskaia, E.B., Campos, M.N., Kipnis, T.L., Da Silva, W.D. J. Leukoc. Biol. (2004)
- Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. Kanakaraj, P., Schafer, P.H., Cavender, D.E., Wu, Y., Ngo, K., Grealish, P.F., Wadsworth, S.A., Peterson, P.A., Siekierka, J.J., Harris, C.A., Fung-Leung, W.P. J. Exp. Med. (1998)
- Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. Asehnoune, K., Strassheim, D., Mitra, S., Kim, J.Y., Abraham, E. J. Immunol. (2004)
- Zinc inhibits interleukin-1-dependent T cell stimulation. Wellinghausen, N., Martin, M., Rink, L. Eur. J. Immunol. (1997)