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ZNF318  -  zinc finger protein 318

Homo sapiens

Synonyms: Endocrine regulatory protein, HRIHFB2436, TZF, ZFP318, Zinc finger protein 318
 
 
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Disease relevance of ZNF318

 

High impact information on ZNF318

  • In Caenorhabditis elegans, a gradient of CCCH tandem zinc finger (TZF) proteins coordinates axis polarization and germline differentiation [4].
  • Here we show that the TZF protein MEX-5, a primary anterior determinant, is an RNA-binding protein that recognizes linear RNA sequences with high affinity but low specificity [4].
  • To evaluate other primary sequence requirements for ARE binding in this novel mRNA-binding domain, we mutated many of the conserved residues within the TZF domain of human TTP and evaluated the effects of these mutations on RNA binding in a cell-free system and TTP-induced mRNA instability in cell transfection experiments [5].
  • Although the function of IAPP is yet unknown, its occurrence in pancreatic endocrine tissue and its partial amino acid sequence identity with calcitonin gene-related peptide (CGRP) suggests an endocrine regulatory effect [6].
  • Although the significance of IAPP is unknown, its occurrence in pancreatic endocrine tissue and partial identity with a known neuropeptide suggests an endocrine regulatory function [7].
 

Biological context of ZNF318

 

Anatomical context of ZNF318

  • Tristetraprolin (TTP), the prototype of a small family of CCCH tandem zinc finger (TZF) domain proteins, is a physiological stimulator of instability of the mRNAs encoding tumor necrosis factor-alpha and granulocyte/macrophage colony-stimulating factor in certain cell types [5].
  • Inhibin, a member of the TGF-beta superfamily, is synthesized in the testis by Sertoli cells and exerts an endocrine regulatory function on pituitary hormone synthesis [12].
  • The growth rate of TTP-transduced Jurkat T cells tended to be slower than that of TZF- or mock-transduced cells [3].
  • Various possibilities are suggested such as a yet unknown ubiquitous fetal/neonatal microbial infection, tolerance induction towards islet cell antigens, an endocrine regulatory function of infiltrated lymphoid cells, and a normal ontogenetic process [13].
  • These growth and inhibitory factors could mediate important autocrine, paracrine and/or endocrine regulatory processes of human uterus [14].
 

Other interactions of ZNF318

References

  1. Obesity at the age of 50 y in men and women exposed to famine prenatally. Ravelli, A.C., van Der Meulen, J.H., Osmond, C., Barker, D.J., Bleker, O.P. Am. J. Clin. Nutr. (1999) [Pubmed]
  2. A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Singh, R.P., Agarwal, R. Mutat. Res. (2004) [Pubmed]
  3. Gene transduction of tristetraprolin or its active domain reduces TNF-alpha production by Jurkat T cells. Suzuki, E., Tsutsumi, A., Goto, D., Matsumoto, I., Ito, S., Otsu, M., Onodera, M., Takahashi, S., Sato, Y., Sumida, T. Int. J. Mol. Med. (2006) [Pubmed]
  4. Molecular Basis of RNA Recognition by the Embryonic Polarity Determinant MEX-5. Pagano, J.M., Farley, B.M., McCoig, L.M., Ryder, S.P. J. Biol. Chem. (2007) [Pubmed]
  5. Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. Lai, W.S., Kennington, E.A., Blackshear, P.J. J. Biol. Chem. (2002) [Pubmed]
  6. Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques. Johnson, K.H., O'Brien, T.D., Hayden, D.W., Jordan, K., Ghobrial, H.K., Mahoney, W.C., Westermark, P. Am. J. Pathol. (1988) [Pubmed]
  7. Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Westermark, P., Wernstedt, C., O'Brien, T.D., Hayden, D.W., Johnson, K.H. Am. J. Pathol. (1987) [Pubmed]
  8. Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid activity in the female rat. A focus on the EDSTAC recommendations. Goldman, J.M., Laws, S.C., Balchak, S.K., Cooper, R.L., Kavlock, R.J. Crit. Rev. Toxicol. (2000) [Pubmed]
  9. Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2. Tao, R.H., Kawate, H., Wu, Y., Ohnaka, K., Ishizuka, M., Inoue, A., Hagiwara, H., Takayanagi, R. Mol. Cell. Endocrinol. (2006) [Pubmed]
  10. Dendritic cells and macrophages in the pituitary and the gonads. Evidence for their role in the fine regulation of the reproductive endocrine response. Hoek, A., Allaerts, W., Leenen, P.J., Schoemaker, J., Drexhage, H.A. Eur. J. Endocrinol. (1997) [Pubmed]
  11. The role of cytokines and hematopoietic growth factors in the autocrine/paracrine regulation of inducible hematopoiesis. Cluitmans, F.H., Esendam, B.H., Veenhof, W.F., Landegent, J.E., Willemze, R., Falkenburg, J.H. Ann. Hematol. (1997) [Pubmed]
  12. A role of inhibin as a tumor suppressor in Sertoli cells: down-regulation upon aging and repression by a viral oncogene. Lopez, P., Vidal, F., Rassoulzadegan, M., Cuzin, F. Oncogene (1999) [Pubmed]
  13. An immunohistochemical study on organized lymphoid cell infiltrates in fetal and neonatal pancreases. A comparison with similar infiltrates found in the pancreas of a diabetic infant. Jansen, A., Voorbij, H.A., Jeucken, P.H., Bruining, G.J., Hooijkaas, H., Drexhage, H.A. Autoimmunity (1993) [Pubmed]
  14. Characterization of human uterus-derived growth substances. Koutsilieris, M., Michaud, J. In Vivo (1990) [Pubmed]
  15. Lack of peptide YY immunoreactivity in adenomatous colonic polyps: evidence in favor of an adenoma-carcinoma sequence. Adrian, T.E., Ballantyne, G.H., Zucker, K.A., Zdon, M.J., Tierney, R., Modlin, I.M. J. Surg. Res. (1988) [Pubmed]
 
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