Gene Review:
FFAR1 - free fatty acid receptor 1
Homo sapiens
Synonyms:
FFA1R, Free fatty acid receptor 1, G-protein coupled receptor 40, GPCR40, GPR40
Schwartz,
Hansen,
Jayawickreme,
Owman,
Briscoe,
Covington,
Eilert,
Elshourbagy,
Briscoe,
Urhammer,
Blask,
Dauchy,
Nilsson,
Vissing,
McKeown,
Meidute-Abaraviciene,
Winzell,
Brown,
Andrews,
Dauchy,
Salehi,
Fornwald,
Ellis,
Hansen,
Tetsumori Yamashima,
Sauer,
Peat,
Andrews,
Littleton,
Corbett,
Shabon,
Murdock,
Krause,
McCoy,
Ammala,
Benson,
Ignar,
Wilson,
Strum,
Briscoe,
Sauls,
Kenakin,
Jenkinson,
Jørgensen,
Spinage,
Pedersen,
Hamid,
Tan,
Tadayyon,
Ignar,
Kotarsky,
Glümer,
Goetz,
Olde,
Borch-Johnsen,
Muir,
Pyke,
Davidson,
Holst,
Ahrén,
Chambers,
Minnick,
Flodgren,
Way,
Szekeres,
Goetz,
Olde,
- Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. Hardy, S., St-Onge, G.G., Joly, E., Langelier, Y., Prentki, M. J. Biol. Chem. (2005)
- GPR40 gene expression in human pancreas and insulinoma. Tomita, T., Masuzaki, H., Noguchi, M., Iwakura, H., Fujikura, J., Tanaka, T., Ebihara, K., Kawamura, J., Komoto, I., Kawaguchi, Y., Fujimoto, K., Doi, R., Shimada, Y., Hosoda, K., Imamura, M., Nakao, K. Biochem. Biophys. Res. Commun. (2005)
- The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing. Covington, D.K., Briscoe, C.A., Brown, A.J., Jayawickreme, C.K. Biochem. Soc. Trans. (2006)
- GPR40 is expressed in glucagon producing cells and affects glucagon secretion. Flodgren, E., Olde, B., Meidute-Abaraviciene, S., Winzell, M.S., Ahrén, B., Salehi, A. Biochem. Biophys. Res. Commun. (2007)
- Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., Tanaka, H., Maruyama, M., Satoh, R., Okubo, S., Kizawa, H., Komatsu, H., Matsumura, F., Noguchi, Y., Shinohara, T., Hinuma, S., Fujisawa, Y., Fujino, M. Nature (2003)
- GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo. Latour, M.G., Alquier, T., Oseid, E., Tremblay, C., Jetton, T.L., Luo, J., Lin, D.C., Poitout, V. Diabetes (2007)
- Fatty Acid Signaling in the {beta}-Cell and Insulin Secretion. Nolan, C.J., Madiraju, M.S., Delghingaro-Augusto, V., Peyot, M.L., Prentki, M. Diabetes (2006)
- A putative link of PUFA, GPR40 and adult-born hippocampal neurons for memory. Yamashima, T. Prog. Neurobiol. (2008)
- Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. Yonezawa, T., Katoh, K., Obara, Y. Biochem. Biophys. Res. Commun. (2004)
- A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Kotarsky, K., Nilsson, N.E., Flodgren, E., Owman, C., Olde, B. Biochem. Biophys. Res. Commun. (2003)
- Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. Sauer, L.A., Dauchy, R.T., Blask, D.E., Krause, J.A., Davidson, L.K., Dauchy, E.M. J. Nutr. (2005)
- Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. Salehi, A., Flodgren, E., Nilsson, N.E., Jimenez-Feltstrom, J., Miyazaki, J., Owman, C., Olde, B. Cell Tissue Res. (2005)
- Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Nilsson, N.E., Kotarsky, K., Owman, C., Olde, B. Biochem. Biophys. Res. Commun. (2003)
- Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5'-O-(3-[35S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist. Stoddart, L.A., Brown, A.J., Milligan, G. Mol. Pharmacol. (2007)
- Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Briscoe, C.P., Peat, A.J., McKeown, S.C., Corbett, D.F., Goetz, A.S., Littleton, T.R., McCoy, D.C., Kenakin, T.P., Andrews, J.L., Ammala, C., Fornwald, J.A., Ignar, D.M., Jenkinson, S. Br. J. Pharmacol. (2006)
- Role of insulin and free fatty acid (FFA) availability on regional FFA kinetics in the human forearm. Capaldo, B., Napoli, R., Di Marino, L., Guida, R., Pardo, F., Saccá, L. J. Clin. Endocrinol. Metab. (1994)
- Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release. Hamid, Y.H., Vissing, H., Holst, B., Urhammer, S.A., Pyke, C., Hansen, S.K., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Schwartz, T.W., Pedersen, O., Hansen, T. Diabet. Med. (2005)
- The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. Briscoe, C.P., Tadayyon, M., Andrews, J.L., Benson, W.G., Chambers, J.K., Eilert, M.M., Ellis, C., Elshourbagy, N.A., Goetz, A.S., Minnick, D.T., Murdock, P.R., Sauls, H.R., Shabon, U., Spinage, L.D., Strum, J.C., Szekeres, P.G., Tan, K.B., Way, J.M., Ignar, D.M., Wilson, S., Muir, A.I. J. Biol. Chem. (2003)
- A family of fatty acid binding receptors. Brown, A.J., Jupe, S., Briscoe, C.P. DNA Cell Biol. (2005)
- GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men. Ogawa, T., Hirose, H., Miyashita, K., Saito, I., Saruta, T. Metab. Clin. Exp. (2005)
- Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion. Tomita, T., Masuzaki, H., Iwakura, H., Fujikura, J., Noguchi, M., Tanaka, T., Ebihara, K., Kawamura, J., Komoto, I., Kawaguchi, Y., Fujimoto, K., Doi, R., Shimada, Y., Hosoda, K., Imamura, M., Nakao, K. Diabetologia (2006)
- Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Schnell, S., Schaefer, M., Sch??fl, C. Mol. Cell. Endocrinol. (2007)