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Gene Review

TPCN1  -  two pore segment channel 1

Homo sapiens

Synonyms: FLJ20612, KIAA1169, TPC1, Two pore calcium channel protein 1, Voltage-dependent calcium channel protein TPC1
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Disease relevance of TPCN1


High impact information on TPCN1


Chemical compound and disease context of TPCN1


Biological context of TPCN1


Anatomical context of TPCN1


Associations of TPCN1 with chemical compounds

  • By this sensitive method retTPC/PTC transcript could be detected in about 500 fg of total RNA of TPC-1, a retTPC/PTC transcript-positive cell line [16].
  • We examined the effect of herbimycin A, a potent inhibitor of tyrosine kinases, on NIH(ret) cells and TPC-1 papillary thyroid carcinoma cells, both of which express the active ret genes [12].
  • When tyrosine kinase activities of the active ret gene products in herbimycin A-treated NIH(ret) and TPC-1 cells were examined in immunocomplex kinase assays, they drastically decreased in both cells as compared with untreated cells [12].
  • Administration of ZD6474 led to an up to 95% reduction of cell number in Hth74, 85% in C643, 90% in FTC133, and 90% in TPC1 (p < 0.05) [17].
  • Administration of ZD1839 led to an up to 90% reduction of cell number in Hth74, 80% in C643, 50% in FTC133, and 90% in TPC1 (p < 0.05) [17].

Regulatory relationships of TPCN1


Other interactions of TPCN1


Analytical, diagnostic and therapeutic context of TPCN1

  • Northern blot analysis showed that TPC1 mRNA (5 kb) was expressed widely [23].
  • Immunohistochemistry of kidney revealed that TPC1 was expressed at inner medullary collecting ducts [23].
  • The effects of BAY 43-9006 on proliferation of human TPC1 and TT thyroid carcinoma cells, which harbor spontaneous oncogenic RET alleles, and on RAT1 fibroblasts transformed with oncogenic RET mutants, including mutants that are resistant to other chemotherapeutic agents, were determined using growth curves and flow cytometry [24].


  1. Interleukin-4 stimulates papillary thyroid cancer cell survival: implications in patients with thyroid cancer and concomitant Graves' disease. Vella, V., Mineo, R., Frasca, F., Mazzon, E., Pandini, G., Vigneri, R., Belfiore, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  2. Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line. Ishizaka, Y., Itoh, F., Tahira, T., Ikeda, I., Ogura, T., Sugimura, T., Nagao, M. Jpn. J. Cancer Res. (1989) [Pubmed]
  3. Proteomic analysis of human thyroid cell lines reveals reduced nuclear localization of Mn-SOD in poorly differentiated thyroid cancer cells. Russo, D., Bisca, A., Celano, M., Talamo, F., Arturi, F., Scipioni, A., Presta, I., Bulotta, S., Ferretti, E., Filetti, S., Scaloni, A., Damante, G., Tell, G. J. Endocrinol. Invest. (2005) [Pubmed]
  4. A generalized transducing thiophage (TPC-1) of a facultative sulfur chemolithotrophic bacterium, Bosea thiooxidans CT5, of alpha-Proteobacteria, isolated from Indian soil. Deb, C., Chakraborty, R., Ghosh, A.N., Mandal, N.C., Mukherjee, T., Roy, P. FEMS Microbiol. Lett. (2003) [Pubmed]
  5. Detection of the PTC/retTPC oncogene in human thyroid cancers. Jhiang, S.M., Caruso, D.R., Gilmore, E., Ishizaka, Y., Tahira, T., Nagao, M., Chiu, I.M., Mazzaferri, E.L. Oncogene (1992) [Pubmed]
  6. Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Ouyang, B., Knauf, J.A., Smith, E.P., Zhang, L., Ramsey, T., Yusuff, N., Batt, D., Fagin, J.A. Clin. Cancer Res. (2006) [Pubmed]
  7. The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines. Park, J.W., Yeh, M.W., Wong, M.G., Lobo, M., Hyun, W.C., Duh, Q.Y., Clark, O.H. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  8. Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid. Soh, E.Y., Duh, Q.Y., Sobhi, S.A., Young, D.M., Epstein, H.D., Wong, M.G., Garcia, Y.K., Min, Y.D., Grossman, R.F., Siperstein, A.E., Clark, O.H. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  9. Effects of histone acetylation on sodium iodide symporter promoter and expression of thyroid-specific transcription factors. Puppin, C., D'Aurizio, F., D'Elia, A.V., Cesaratto, L., Tell, G., Russo, D., Filetti, S., Ferretti, E., Tosi, E., Mattei, T., Pianta, A., Pellizzari, L., Damante, G. Endocrinology (2005) [Pubmed]
  10. Lack of PTC gene (ret proto-oncogene rearrangement) in human thyroid tumors. Namba, H., Yamashita, S., Pei, H.C., Ishikawa, N., Villadolid, M.C., Tominaga, T., Kimura, H., Tsuruta, M., Yokoyama, N., Izumi, M. Endocrinol. Jpn. (1991) [Pubmed]
  11. Molecular and cytogenetic characterization of a t(1;10;21) translocation in the human papillary thyroid cancer cell line TPC-1 expressing the ret/H4 chimeric transcript. Jossart, G.H., Greulich, K.M., Siperstein, A.E., Duh, Q., Clark, O.H., Weier, H.U. Surgery (1995) [Pubmed]
  12. Inhibition of ret tyrosine kinase activity by herbimycin A. Taniguchi, M., Uehara, Y., Matsuyama, M., Takahashi, M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  13. Modulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by chemotherapy in thyroid cancer cell lines. Park, J.W., Wong, M.G., Lobo, M., Hyun, W.C., Duh, Q.Y., Clark, O.H. Thyroid (2003) [Pubmed]
  14. Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1. Puppin, C., Arturi, F., Ferretti, E., Russo, D., Sacco, R., Tell, G., Damante, G., Filetti, S. Endocrinology (2004) [Pubmed]
  15. Establishment and characterization of two cell lines derived from human transitional cell carcinoma. Chang, J., Sui, Z., Ma, T., Ma, K., Zhang, X., Wang, J., Dong, K., Yao, Q. Chin. Med. J. (1995) [Pubmed]
  16. Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method. Ishizaka, Y., Kobayashi, S., Ushijima, T., Hirohashi, S., Sugimura, T., Nagao, M. Oncogene (1991) [Pubmed]
  17. Targeting the EGF/VEGF-R system by tyrosine-kinase inhibitors-a novel antiproliferative/antiangiogenic strategy in thyroid cancer. Hoffmann, S., Gl??ser, S., Wunderlich, A., Lingelbach, S., Dietrich, C., Burchert, A., M??ller, H., Rothmund, M., Zielke, A. Langenbeck's archives of surgery / Deutsche Gesellschaft f??r Chirurgie. (2006) [Pubmed]
  18. Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways. Iwahashi, N., Murakami, H., Nimura, Y., Takahashi, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  19. Transforming growth factor-beta1 and activin A generate antiproliferative signaling in thyroid cancer cells. Matsuo, S.E., Leoni, S.G., Colquhoun, A., Kimura, E.T. J. Endocrinol. (2006) [Pubmed]
  20. A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1. Jossart, G.H., O'Brien, B., Cheng, J.F., Tong, Q., Jhiang, S.M., Duh, Q., Clark, O.H., Weier, H.U. Cytogenet. Cell Genet. (1996) [Pubmed]
  21. Intercellular adhesion molecule-1 is upregulated via the protein kinase C pathway in human thyroid carcinoma cell lines. Bassi, V., De Riu, S., Feliciello, A., Altomonte, M., Allevato, G., Rossi, G., Fenzi, G.F. Thyroid (1998) [Pubmed]
  22. Thyroid peroxidase expression and DNA polymorphisms in thyroid cancer. Smanik, P.A., Fithian, L.J., Jhiang, S.M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  23. Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. Ishibashi, K., Suzuki, M., Imai, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  24. BAY 43-9006 inhibition of oncogenic RET mutants. Carlomagno, F., Anaganti, S., Guida, T., Salvatore, G., Troncone, G., Wilhelm, S.M., Santoro, M. J. Natl. Cancer Inst. (2006) [Pubmed]
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