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Gene Review

SMARCA1  -  SWI/SNF related, matrix associated, actin...

Homo sapiens

Synonyms: ATP-dependent helicase SMARCA1, ISWI, NURF140, Nucleosome-remodeling factor subunit SNF2L, SNF2L, ...
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High impact information on SMARCA1

  • Maintenance of genomic methylation requires a SWI2/SNF2-like protein [1].
  • We have now identified a homolog of JBP1, JBP2, containing a domain related to the SWI2/SNF2 family of chromatin remodeling proteins that is upregulated in bloodstream form cells and interacts with nuclear chromatin [2].
  • We show that expression of JBP2 in procyclic form cells leads to de novo J synthesis within telomeric regions of the chromosome and that this activity is inhibited after mutagenesis of conserved residues critical for SWI2/SNF2 function [2].
  • Regulation of trypanosome DNA glycosylation by a SWI2/SNF2-like protein [2].
  • Mot1 is a conserved Snf2/Swi2-related transcriptional regulator that uses ATP hydrolysis to displace TATA-binding protein (TBP) from DNA [3].

Biological context of SMARCA1


Anatomical context of SMARCA1


Associations of SMARCA1 with chemical compounds

  • In contrast, both SNF2L transcript and SNF2L protein levels are rapidly increased in granulosa cells of the mouse ovary 8 h after human chorionic gonadotropin treatment, and continue to be expressed 36 h later within the functional corpus luteum [7].
  • Many members of the SWI2/SNF2 family of adenosine triphosphatases participate in the assembly/disassembly of multiprotein complexes involved in the DNA metabolic processes of transcription, recombination, repair, and chromatin remodeling [10].
  • Both activation and repression require the action of other chromatin remodeling engines of the switch 2/sucrose non-fermentable 2 (SWI2/SNF2) class [11].

Other interactions of SMARCA1

  • Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene [12].
  • Moreover, PCAF and the Brahma/SWI2-related protein BRG-1, which is a key factor of the human ATP-dependent chromatin remodelling complex SWI/SNF, synergistically up-regulate the enhancer A [13].
  • Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2 [14].

Analytical, diagnostic and therapeutic context of SMARCA1


  1. Maintenance of genomic methylation requires a SWI2/SNF2-like protein. Jeddeloh, J.A., Stokes, T.L., Richards, E.J. Nat. Genet. (1999) [Pubmed]
  2. Regulation of trypanosome DNA glycosylation by a SWI2/SNF2-like protein. DiPaolo, C., Kieft, R., Cross, M., Sabatini, R. Mol. Cell (2005) [Pubmed]
  3. Snf2/Swi2-related ATPase Mot1 drives displacement of TATA-binding protein by gripping DNA. Sprouse, R.O., Brenowitz, M., Auble, D.T. EMBO J. (2006) [Pubmed]
  4. A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. Barak, O., Lazzaro, M.A., Cooch, N.S., Picketts, D.J., Shiekhattar, R. J. Biol. Chem. (2004) [Pubmed]
  5. Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae. Okabe, I., Bailey, L.C., Attree, O., Srinivasan, S., Perkel, J.M., Laurent, B.C., Carlson, M., Nelson, D.L., Nussbaum, R.L. Nucleic Acids Res. (1992) [Pubmed]
  6. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. Wang, W., Côté, J., Xue, Y., Zhou, S., Khavari, P.A., Biggar, S.R., Muchardt, C., Kalpana, G.V., Goff, S.P., Yaniv, M., Workman, J.L., Crabtree, G.R. EMBO J. (1996) [Pubmed]
  7. The Imitation Switch Protein SNF2L Regulates Steroidogenic Acute Regulatory Protein Expression during Terminal Differentiation of Ovarian Granulosa Cells. Lazzaro, M.A., P??pin, D., Pescador, N., Murphy, B.D., Vanderhyden, B.C., Picketts, D.J. Mol. Endocrinol. (2006) [Pubmed]
  8. CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. Banting, G.S., Barak, O., Ames, T.M., Burnham, A.C., Kardel, M.D., Cooch, N.S., Davidson, C.E., Godbout, R., McDermid, H.E., Shiekhattar, R. Hum. Mol. Genet. (2005) [Pubmed]
  9. Cytoplasm of sea urchin unfertilized eggs contains a nucleosome remodeling activity. Medina, R., Gutiérrez, J., Puchi, M., Imschenetzky, M., Montecino, M. J. Cell. Biochem. (2001) [Pubmed]
  10. A eukaryotic SWI2/SNF2 domain, an exquisite detector of double-stranded to single-stranded DNA transition elements. Muthuswami, R., Truman, P.A., Mesner, L.D., Hockensmith, J.W. J. Biol. Chem. (2000) [Pubmed]
  11. Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription. Collingwood, T.N., Urnov, F.D., Wolffe, A.P. J. Mol. Endocrinol. (1999) [Pubmed]
  12. Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. Wang, F., Zhang, R., Beischlag, T.V., Muchardt, C., Yaniv, M., Hankinson, O. J. Biol. Chem. (2004) [Pubmed]
  13. The histone acetyltransferase activity of PCAF cooperates with the brahma/SWI2-related protein BRG-1 in the activation of the enhancer A of the MHC class I promoter. Brockmann, D., Lehmkühler, O., Schmücker, U., Esche, H. Gene (2001) [Pubmed]
  14. Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2. Ichinose, H., Garnier, J.M., Chambon, P., Losson, R. Gene (1997) [Pubmed]
  15. Structure-function analysis of SWI2/SNF2 enzymes. Dürr, H., Hopfner, K.P. Meth. Enzymol. (2006) [Pubmed]
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