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Gene Review:

Basp1 - brain abundant, membrane attached signal...

Mus musculus

Synonyms: 22 kDa neuronal tissue-enriched acidic protein, 2610024P12Rik, Brain acid soluble protein 1, CAP-23, CAP23, ...

Frey, D. et al., Khan, T.K. et al., Bomze, H.M. et al., Tejero-Díez, P. et al., Morris, J.S. et al., et al.

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Disease relevance of Basp1

Here we show that co-expressing two major growth cone proteins, GAP-43 and CAP-23, can elicit long axon extension by adult dorsal root ganglion (DRG) neurons in vitro [1].

High impact information on Basp1

Cultured sensory neurons lacking CAP23 exhibited striking alterations in neurite outgrowth that were phenocopied by low doses of cytochalasin D [2].
A detailed analysis of such cultures revealed common and unique functions of CAP23 and GAP43 on the actin cytoskeleton and neurite outgrowth [2].
Knockout mice lacking CAP23 exhibited a pronounced and complex phenotype, including a defect to produce stimulus-induced nerve sprouting at the adult neuromuscular junction [2].
GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism [3].
The cholesterol-binding protein NAP-22 is a major component of the detergent-insoluble low-density fraction of rat brain [4].

Anatomical context of Basp1

Here, we show that CAP23 is functionally related to GAP43, and plays a critical role to regulate nerve sprouting and the actin cytoskeleton [2].
Binding of NAP-22, a calmodulin-binding neuronal protein, to raft-like domains in model membranes [4].
This study suggests that NAP-22 binding may be employed to image cholesterol-rich regions, such as caveolae/rafts, on the plasma membrane of cells, and preliminary efforts in that direction are presented [4].

Associations of Basp1 with chemical compounds

This method can be applied to other proteins which show similar characteristics, such as myristoylated alanine-rich C kinase, NAP-22, and Neurogranin, among others [5].

Other interactions of Basp1

NAP-22 also protects the cholesterol-rich domains during extraction by methyl-beta-cyclodextrin [4].

Analytical, diagnostic and therapeutic context of Basp1

Expression of these genes was confirmed by RT-PCR and Western blotting, and the cellular distribution of Sprr1A and BASP1 was demonstrated by immunohistochemistry [6].

References

Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons. Bomze, H.M., Bulsara, K.R., Iskandar, B.J., Caroni, P., Skene, J.H. Nat. Neurosci. (2001) [Pubmed]
Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity. Frey, D., Laux, T., Xu, L., Schneider, C., Caroni, P. J. Cell Biol. (2000) [Pubmed]
GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. Laux, T., Fukami, K., Thelen, M., Golub, T., Frey, D., Caroni, P. J. Cell Biol. (2000) [Pubmed]
Binding of NAP-22, a calmodulin-binding neuronal protein, to raft-like domains in model membranes. Khan, T.K., Yang, B., Thompson, N.L., Maekawa, S., Epand, R.M., Jacobson, K. Biochemistry (2003) [Pubmed]
Microscale purification of proteins exhibiting anomalous electrophoretic migration: application to the analysis of GAP-43 phosphorylation. Tejero-Díez, P., Rodríguez-Sánchez, P., Díez-Guerra, F.J. Anal. Biochem. (1999) [Pubmed]
Involvement of axonal guidance proteins and their signaling partners in the developing mouse mammary gland. Morris, J.S., Stein, T., Pringle, M.A., Davies, C.R., Weber-Hall, S., Ferrier, R.K., Bell, A.K., Heath, V.J., Gusterson, B.A. J. Cell. Physiol. (2006) [Pubmed]

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BASP1	Bos taurus
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BASP1	Homo sapiens
LOC700114	Macaca mulatta
BASP1	Pan troglodytes
LOC100910172	Rattus norvegicus

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