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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 73 documents. Results 1 - 10.

Caenorhabditis elegans
Gene: ... decrease in CTD phosphorylation and embryonic transcription, and severe loss of cdk- 7 activity blocks all...High impact information on cdk- 7 cdk- 7 Is required for mRNA transcription and cell cycle... in Caenorhabditis elegans cdk- 7 and have used it to analyze the role of cdk- 7 in embryonic blastomeres, where cell...
Drosophila melanogaster
Gene: ... High impact information on Cdk7 Vertebrate Cdk7 is also known to be part of TFIIH. T- loop phosphorylation stabilizes the CDK7- cyclin H- MAT1 complex in vivo and regulates its CTD kinase activity. Mutation of both phosphorylation sites causes temperature- dependent dissociation of CDK7 complexes... / Synonyms: CDK7; DmCDK7; DmCdk7
Homo sapiens
Gene: ... Disease relevance of CDK7 HIV- 1 Tat- associated RNA polymerase C- terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat- mediated transcription. Cyclin- dependent kinase activating kinase/ Cdk7... on CDK7 We demonstrate that the XPD mutation alters cdk7 function in RARalpha phosphorylation. However...
Xenopus (Silurana) tropicalis
Gene: ... High impact information on cdk7 In the absence of MAT- 1, phosphorylation of the T- loop appears to be required for cdk7 to bind cyclin H. Phosphorylation of both residues does not require cyclin H binding...RNAs encoding Xenopus cdk7, cyclin H and MAT1. However, CAK may also exist in oocytes as heterodimeric complexes...
Rattus norvegicus
Gene: ... and mRNAs corresponding to all other Cdks examined( Cdk2, Cdk4, Cdk7, Cdk8) throughout...High impact information on Cdk7 In addition, 17N Ras markedly inhibited phosphorylation of the C... by down- regulation of its principal kinase, cyclin- dependent kinase 7( Cdk7). Cdk6 and Cdk7 activities...
Mus musculus
Gene: ... Disease relevance of Cdk7 A variant mouse plasmacytoma( MPC )- associated translocation chromosome... chromosome in the CAK TEPC 1198 mouse plasmacytoma, as described earlier. High impact information on Cdk7... activating residue of CDK7. Levels of the cdk inhibitor p27Klp1 increase in cAMP- treated cells, and its...
Caenorhabditis remanei
Homo sapiens
Gene: ... CDK7- CycH switched its substrate preference to favour the pol II large subunit C- terminal domain... for CDK7- CycH, also acts to modulate CAK substrate specificity. Sequencing of MAT1 reveals a putative... for ternary complex formation with CDK7- cyclin H. Chemical compound and disease context of MNAT1 Members... / Synonyms: CDK7/cyclin-H assembly factor
Caenorhabditis briggsae
MeSH term: ... at this stage. We have isolated a temperature- sensitive mutation in Caenorhabditis elegans cdk- 7 and have used it to analyze the role of cdk- 7 in embryonic blastomeres, where cell cycle progression is independent... is sequentially restricted to this blastomere. By contrast, glp- 1 mRNA is present in all blastomeres until the 8...


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