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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cdk7  -  cyclin-dependent kinase 7

Rattus norvegicus

Synonyms: 39 protein kinase, CDK-activating kinase 1, Cak, Cak1, Cell division protein kinase 7, ...
 
 
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High impact information on Cdk7

  • In addition, 17N Ras markedly inhibited phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (pol II), known to regulate transcript elongation, accompanied by down-regulation of its principal kinase, cyclin-dependent kinase 7 (Cdk7) [1].
  • Cdk6 and Cdk7 activities remained unchanged in the process from normal liver to HCC [2].
  • Knockdown of RasGAP or FLN-C, or severing their interaction, resulted in down-regulation of the RNA polymerase II kinase, cyclin-dependent kinase 7 (Cdk7) [3].
  • Cdk-activating kinase did not rescue Cdk4/6 activity [4].
  • In the lens epithelium, we detected proteins and mRNAs corresponding to all other Cdks examined (Cdk2, Cdk4, Cdk7, Cdk8) throughout this developmental period [5].

References

  1. A Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy. Abdellatif, M., Packer, S.E., Michael, L.H., Zhang, D., Charng, M.J., Schneider, M.D. Mol. Cell. Biol. (1998) [Pubmed]
  2. Hepatocellular carcinoma cell cycle: study of Long-Evans cinnamon rats. Masaki, T., Shiratori, Y., Rengifo, W., Igarashi, K., Matsumoto, K., Nishioka, M., Hatanaka, Y., Omata, M. Hepatology (2000) [Pubmed]
  3. An alliance between Ras GTPase-activating protein, filamin C, and Ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth. Lypowy, J., Chen, I.Y., Abdellatif, M. J. Biol. Chem. (2005) [Pubmed]
  4. The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression. Obaya, A.J., Kotenko, I., Cole, M.D., Sedivy, J.M. J. Biol. Chem. (2002) [Pubmed]
  5. Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation. Gao, C.Y., Rampalli, A.M., Cai, H.C., He, H.Y., Zelenka, P.S. Exp. Eye Res. (1999) [Pubmed]
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