Gene Review:
CDK7 - cyclin-dependent kinase 7
Homo sapiens
Synonyms:
39 kDa protein kinase, CAK, CAK1, CDK-activating kinase 1, CDKN7, ...
- HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription. Nekhai, S., Zhou, M., Fernandez, A., Lane, W.S., Lamb, N.J., Brady, J., Kumar, A. Biochem. J. (2002)
- Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells. Bicaku, E., Patel, R., Acevedo-Duncan, M. Tissue & cell. (2005)
- Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Levedakou, E.N., He, M., Baptist, E.W., Craven, R.J., Cance, W.G., Welcsh, P.L., Simmons, A., Naylor, S.L., Leach, R.J., Lewis, T.B. Oncogene (1994)
- XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha. Keriel, A., Stary, A., Sarasin, A., Rochette-Egly, C., Egly, J.M. Cell (2002)
- Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Rochette-Egly, C., Adam, S., Rossignol, M., Egly, J.M., Chambon, P. Cell (1997)
- The Cdk-activating kinase (CAK) from budding yeast. Kaldis, P., Sutton, A., Solomon, M.J. Cell (1996)
- A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Fisher, R.P., Morgan, D.O. Cell (1994)
- The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Roy, R., Adamczewski, J.P., Seroz, T., Vermeulen, W., Tassan, J.P., Schaeffer, L., Nigg, E.A., Hoeijmakers, J.H., Egly, J.M. Cell (1994)
- Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. He, Q., Zhang, P., Zou, L., Li, H., Wang, X., Zhou, S., Fornander, T., Skog, S. Oncol. Rep. (2005)
- Regulation of CDK7 substrate specificity by MAT1 and TFIIH. Yankulov, K.Y., Bentley, D.L. EMBO J. (1997)
- Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Garrett, S., Barton, W.A., Knights, R., Jin, P., Morgan, D.O., Fisher, R.P. Mol. Cell. Biol. (2001)
- Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. Yu, J., Guo, Q.L., You, Q.D., Zhao, L., Gu, H.Y., Yang, Y., Zhang, H.W., Tan, Z., Wang, X. Carcinogenesis (2007)
- A cyclin associated with the CDK-activating kinase MO15. Mäkelä, T.P., Tassan, J.P., Nigg, E.A., Frutiger, S., Hughes, G.J., Weinberg, R.A. Nature (1994)
- Requirements for cdk7 in the assembly of cdk1/cyclin B and activation of cdk2 revealed by chemical genetics in human cells. Larochelle, S., Merrick, K.A., Terret, M.E., Wohlbold, L., Barboza, N.M., Zhang, C., Shokat, K.M., Jallepalli, P.V., Fisher, R.P. Mol. Cell (2007)
- Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor. Yee, A., Nichols, M.A., Wu, L., Hall, F.L., Kobayashi, R., Xiong, Y. Cancer Res. (1995)
- The crystal structure of human CDK7 and its protein recognition properties. Lolli, G., Lowe, E.D., Brown, N.R., Johnson, L.N. Structure (Camb.) (2004)
- Analysis of CAK activities from human cells. Kaldis, P., Solomon, M.J. Eur. J. Biochem. (2000)
- Protein kinase C inhibits the CAK-CDK2 cyclin-dependent kinase cascade and G1/S cell cycle progression in human diploid fibroblasts. Hamada, K., Takuwa, N., Zhou, W., Kumada, M., Takuwa, Y. Biochim. Biophys. Acta (1996)
- Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II. Egyházi, E., Ossoinak, A., Lee, J.M., Greenleaf, A.L., Mäkelä, T.P., Pigon, A. Exp. Cell Res. (1998)
- Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Zhou, M., Halanski, M.A., Radonovich, M.F., Kashanchi, F., Peng, J., Price, D.H., Brady, J.N. Mol. Cell. Biol. (2000)
- Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Krystof, V., McNae, I.W., Walkinshaw, M.D., Fischer, P.M., Müller, P., Vojtesek, B., Orság, M., Havlícek, L., Strnad, M. Cell. Mol. Life Sci. (2005)
- Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. Wang, J., Lv, X.W., Shi, J.P., Hu, X.S. World J. Gastroenterol. (2007)
- Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Liang, Y.C., Tsai, S.H., Chen, L., Lin-Shiau, S.Y., Lin, J.K. Biochem. Pharmacol. (2003)
- Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Reardon, J.T., Ge, H., Gibbs, E., Sancar, A., Hurwitz, J., Pan, Z.Q. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Cyclin H is targeted to the nucleus by C-terminal nuclear localization sequences. Krempler, A., Kartarius, S., Günther, J., Montenarh, M. Cell. Mol. Life Sci. (2005)
- c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mateyak, M.K., Obaya, A.J., Sedivy, J.M. Mol. Cell. Biol. (1999)
- The amino terminus of Cdk2 binds p21. Moskowitz, N.K., Borao, F.J., Dardashti, O., Cohen, H.D., Germino, F.J. Oncol. Res. (1996)
- p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Ko, L.J., Shieh, S.Y., Chen, X., Jayaraman, L., Tamai, K., Taya, Y., Prives, C., Pan, Z.Q. Mol. Cell. Biol. (1997)
- MAT1-modulated cyclin-dependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth. Zhang, S., He, Q., Peng, H., Tedeschi-Blok, N., Triche, T.J., Wu, L. Cancer Res. (2004)
- Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha. Wang, J.G., Barsky, L.W., Davicioni, E., Weinberg, K.I., Triche, T.J., Zhang, X.K., Wu, L. FASEB J. (2006)
- p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. Liu, Y., Wu, C., Galaktionov, K. J. Biol. Chem. (2004)
- Activation of CDK-activating kinase is dependent on interaction with H-type cyclins in plants. Yamaguchi, M., Fabian, T., Sauter, M., Bhalerao, R.P., Schrader, J., Sandberg, G., Umeda, M., Uchimiya, H. Plant J. (2000)
- CDK4/cyclin D1/PCNA complexes during staurosporine-induced G1 arrest and G0 arrest of human fibroblasts. Gadbois, D.M., Peterson, S., Bradbury, E.M., Lehnert, B.E. Exp. Cell Res. (1995)
- Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm. Yang, E.S., Burnstein, K.L. J. Biol. Chem. (2003)
- p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes. Shuttleworth, J., Godfrey, R., Colman, A. EMBO J. (1990)
- Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Kim, K.K., Chamberlin, H.M., Morgan, D.O., Kim, S.H. Nat. Struct. Biol. (1996)
- The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Wohlbold, L., Larochelle, S., Liao, J.C., Livshits, G., Singer, J., Shokat, K.M., Fisher, R.P. Cell Cycle (2006)
- Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins. Korsisaari, N., Mäkelä, T.P. J. Biol. Chem. (2000)
- Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase. Wu, L., Yee, A., Liu, L., Carbonaro-Hall, D., Venkatesan, N., Tolo, V.T., Hall, F.L. Oncogene (1994)