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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cdk7  -  Cyclin-dependent kinase 7

Drosophila melanogaster

Synonyms: CD 7, CDK7, CG3319, DmCDK7, DmCdk7, ...
 
 
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High impact information on Cdk7

  • Vertebrate Cdk7 is also known to be part of TFIIH [1].
  • T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity [2].
  • Mutation of both phosphorylation sites causes temperature-dependent dissociation of CDK7 complexes and lethality [2].
  • While cell cycle regulation is not sensitive to our manipulations of Cdk7 activity, it suggests that a distinct pool of CAK activity that is unaffected by expression of the cdk7(DN) mutants is present in these embryos [3].
  • Moreover, Xpd is downregulated at the beginning of mitosis when Cdk1, a cell cycle target of Cdk7, is most active [4].
 

Biological context of Cdk7

  • Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo [5].
 

Enzymatic interactions of Cdk7

  • As the kinase subunit of TFIIH, Cdk7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II [4].

References

  1. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Larochelle, S., Pandur, J., Fisher, R.P., Salz, H.K., Suter, B. Genes Dev. (1998) [Pubmed]
  2. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. Larochelle, S., Chen, J., Knights, R., Pandur, J., Morcillo, P., Erdjument-Bromage, H., Tempst, P., Suter, B., Fisher, R.P. EMBO J. (2001) [Pubmed]
  3. Dominant-negative mutants reveal a role for the Cdk7 kinase at the mid-blastula transition in Drosophila embryos. Leclerc, V., Raisin, S., Léopold, P. EMBO J. (2000) [Pubmed]
  4. Xpd/Ercc2 regulates CAK activity and mitotic progression. Chen, J., Larochelle, S., Li, X., Suter, B. Nature (2003) [Pubmed]
  5. Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo. Schwartz, B.E., Larochelle, S., Suter, B., Lis, J.T. Mol. Cell. Biol. (2003) [Pubmed]
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