Your search matched a total of 83 documents. Results 1 - 10.
Homo sapiens
Gene: ... Disease relevance of JAK3 In XSCID and SCID resulting from mutations in JAK3, which encodes a Janus... membrane protein 1 of Epstein- Barr virus interacts with JAK3 and activates STAT proteins. Additionally, JAK3 was detected in lysates from bone marrow lymphoblasts of patients with B cell precursor acute... / Synonyms: JAK-3; JAK3_HUMAN; Tyrosine-protein kinase JAK3
Mus musculus
Gene: ... Disease relevance of Jak3 Jak3- deficient mice had profound reductions in thymocytes and severe B... ), and the residual T cells and B cells were functionally deficient. Mice deficient in Jak3 exhibit a SCID phenotype but harbor a residual B220+ splenic lymphocyte population. Mice lacking Jak3 exhibit splenomegaly by 4 months... / Synonyms: JAK-3; Tyrosine-protein kinase JAK3
Rattus norvegicus
Gene: ... High impact information on Jak3 Analysis of T cell lysates by immunoprecipitation with specific Abs and subsequent immunoblotting indicated marked reduction of tyrosine phosphorylation of Jak3 and STAT5 mediated... and has four known members: JAK1, JAK2, JAK3, and Tyk2. Transfection with either JAK1, JAK2, or JAK3... / Synonyms: JAK-3; Tyrosine-protein kinase JAK3
Gallus gallus
Gene: ... High impact information on JAK3 Molecular cloning of a chicken JAK homolog from activated T cells. Chicken JAK( cJAK) contains a double catalytic domain that is characteristic of the JAK family of tyrosine kinases. Therefore, we examined whether these growth factors mediate their effects in the lens through...
MeSH term: ... of the Jak- 3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Finally...). It is well known that all- trans- retinoic acid( ATRA) can induce myeloid cell differentiation in acute... progenitor kinase ), which is expressed in all stages of the B lineage and in myeloid cells. P- selectin...
MeSH term: ... for the treatment of severe combined immunodeficiency. In XSCID and SCID resulting from mutations in JAK3, which... syndrome. We used a mouse model of Jak3- deficient SCID to test a gene therapy approach for treatment... mycobacteria grew rapidly and progressively in all organs, as did BCG, although at a slower rate. However, H37...
MeSH term: ... Disease relevance of Hematopoietic Stem Cells Transfer of a Jak3 retroviral vector to repopulating hematopoietic stem cells resulted in increased numbers of T and B lymphocytes, reversal of hypogammaglobulinemia, restoration of T- cell activation upon stimulation with mitogens, and development of an antigen- specific...
Homo sapiens
Gene: ... interactions of IL2 Neither Jak1 nor Jak3 was phosphorylated after IL- 2 stimulation of an Epstein- Barr virus... Furthermore, Jak3- negative fibroblasts expressing reconstituted IL- 2R became responsive to IL- 2 after the additional expression of Jak3 complementary DNA. Stimulation with IL- 2 induces the tyrosine phosphorylation...
Chemical compound: ... infection in vivo. While Jak3 SCID patients possess mature peripheral B cells, we demonstrate that the Jak3...
MeSH term: ... of an influenza B virus gene. A JAK3 -/- SCID mouse model for the human disease has been used to test whether transplant with retrovirally transduced bone marrow( BM) cells( JAK3 BMT) could restore immunity... treated with rimantadine. Ten NH2- terminal residues are conserved in all strains of influenza A virus...
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Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann
