Gene Review:
Jak3 - Janus kinase 3
Mus musculus
Synonyms:
JAK-3, Tyrosine-protein kinase JAK3, fae, wil
Brooimans,
van der Slot,
van den Berg,
Zegers,
Yamaoka,
Min,
Zhou,
Paul,
O'shea,
Soldevila,
Licona,
Salgado,
Ramírez,
Chávez,
García-Zepeda,
Thompson,
Cubbon,
Cummings,
Wicker,
Frankshun,
Cunningham,
Cameron,
Meinke,
Liverton,
Weng,
DeMartino,
Thomis,
Berg,
Koskimies,
Spiess,
Lahti,
Huhtaniemi,
Ivell,
- Defective lymphoid development in mice lacking Jak3. Nosaka, T., van Deursen, J.M., Tripp, R.A., Thierfelder, W.E., Witthuhn, B.A., McMickle, A.P., Doherty, P.C., Grosveld, G.C., Ihle, J.N. Science (1995)
- Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Carpino, N., Thierfelder, W.E., Chang, M.S., Saris, C., Turner, S.J., Ziegler, S.F., Ihle, J.N. Mol. Cell. Biol. (2004)
- Dysregulated myelopoiesis in mice lacking Jak3. Grossman, W.J., Verbsky, J.W., Yang, L., Berg, L.J., Fields, L.E., Chaplin, D.D., Ratner, L. Blood (1999)
- Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development. Wen, R., Wang, D., McKay, C., Bunting, K.D., Marine, J.C., Vanin, E.F., Zambetti, G.P., Korsmeyer, S.J., Ihle, J.N., Cleveland, J.L. Mol. Cell. Biol. (2001)
- Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Bunting, K.D., Sangster, M.Y., Ihle, J.N., Sorrentino, B.P. Nat. Med. (1998)
- Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Witthuhn, B.A., Silvennoinen, O., Miura, O., Lai, K.S., Cwik, C., Liu, E.T., Ihle, J.N. Nature (1994)
- Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Thomis, D.C., Gurniak, C.B., Tivol, E., Sharpe, A.H., Berg, L.J. Science (1995)
- Development of autologous, oligoclonal, poorly functioning T lymphocytes in a patient with autosomal recessive severe combined immunodeficiency caused by defects of the Jak3 tyrosine kinase. Brugnoni, D., Notarangelo, L.D., Sottini, A., Airò, P., Pennacchio, M., Mazzolari, E., Signorini, S., Candotti, F., Villa, A., Mella, P., Vezzoni, P., Cattaneo, R., Ugazio, A.G., Imberti, L. Blood (1998)
- Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function. Tsujino, S., Di Santo, J.P., Takaoka, A., McKernan, T.L., Noguchi, S., Taya, C., Yonekawa, H., Saito, T., Taniguchi, T., Fujii, H. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3. Brown, M.P., Nosaka, T., Tripp, R.A., Brooks, J., van Deursen, J.M., Brenner, M.K., Doherty, P.C., Ihle, J.N. Blood (1999)
- IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor. Huang, Z., Xin, J., Coleman, J., Huang, H. J. Immunol. (2005)
- Role of common cytokine receptor gamma chain (gamma(c))- and Jak3-dependent signaling in the proliferation and survival of murine mast cells. Suzuki, K., Nakajima, H., Watanabe, N., Kagami, S., Suto, A., Saito, Y., Saito, T., Iwamoto, I. Blood (2000)
- Jak3 negatively regulates dendritic-cell cytokine production and survival. Yamaoka, K., Min, B., Zhou, Y.J., Paul, W.E., O'shea, J.J. Blood (2005)
- Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. Levin, S.D., Koelling, R.M., Friend, S.L., Isaksen, D.E., Ziegler, S.F., Perlmutter, R.M., Farr, A.G. J. Immunol. (1999)
- Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Thompson, J.E., Cubbon, R.M., Cummings, R.T., Wicker, L.S., Frankshun, R., Cunningham, B.R., Cameron, P.M., Meinke, P.T., Liverton, N., Weng, Y., DeMartino, J.A. Bioorg. Med. Chem. Lett. (2002)
- The role of Jak3 in lymphoid development, activation, and signaling. Thomis, D.C., Berg, L.J. Curr. Opin. Immunol. (1997)
- Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. Siemasko, K., Chong, A.S., Jäck, H.M., Gong, H., Williams, J.W., Finnegan, A. J. Immunol. (1998)
- The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Chen, M., Cheng, A., Chen, Y.Q., Hymel, A., Hanson, E.P., Kimmel, L., Minami, Y., Taniguchi, T., Changelian, P.S., O'Shea, J.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Possible mechanism for the alpha subunit of the interleukin-2 receptor (CD25) to influence interleukin-2 receptor signal transduction. Ellery, J.M., Nicholls, P.J. Immunol. Cell Biol. (2002)
- Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals. Mayack, S.R., Berg, L.J. J. Immunol. (2006)
- Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. Soldevila, G., Licona, I., Salgado, A., Ramírez, M., Chávez, R., García-Zepeda, E. Immunology (2004)
- Revised exon-intron structure of human JAK3 locus. Brooimans, R.A., van der Slot, A.J., van den Berg, A.J., Zegers, B.J. Eur. J. Hum. Genet. (1999)
- Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells. Wang, L.H., Kirken, R.A., Yang, X.Y., Erwin, R.A., DaSilva, L., Yu, C.R., Farrar, W.L. Blood (2000)
- The mouse relaxin-like factor gene and its promoter are located within the 3' region of the JAK3 genomic sequence. Koskimies, P., Spiess, A.N., Lahti, P., Huhtaniemi, I., Ivell, R. FEBS Lett. (1997)
- Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1). Cetkovic-Cvrlje, M., Dragt, A.L., Uckun, F.M. Arzneimittel-Forschung. (2003)