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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 330 documents. Results 1 - 10.

Homo sapiens
Gene: ... ) fuses PML, a novel gene, with RAR alpha, a retinoic acid receptor gene. All- trans- retinoic acid( RA...Disease relevance of PML A unique mRNA produced in leukemic cells from a t( 15; 17) acute... alpha) and a myeloid gene product called PML. Marrow mononuclear cells and reverse transcription...
Mus musculus
Gene: ... , all the PML/ RARalpha transgenic mice have an abnormal hematopoiesis that can best be described... bodies, a phenotype reversed by treatment with all trans retinoic acid( ATRA). Inducible expression... proapoptotic stimuli. Clinical remissions induced with all- trans retinoic acid( RA) treatment in acute... / Synonyms: Protein PML
PML1  -  Pml1p
Saccharomyces cerevisiae S288c
Gene: ... High impact information on PML1 We also demonstrate here that the 560- amino- acid PML1 isoform functions as a transcriptional repressor when fused to the GAL4 DNA- binding domain and that wild- type IE1 inhibits the repressor function of PML1 in transient cotransfection assays....
Saccharomyces cerevisiae S288c
Gene: ... High impact information on PML39 Moreover, pml39delta partially rescues the thermosensitive phenotypes of messenger ribonucleoparticles( mRNPs) assembly mutants, indicating that PML39 deletion also... a previously uncharacterized Saccharomyces cerevisiae open reading frame( renamed PML39) that displays...
Burkholderia pseudomallei K96243
Gene: ... High impact information on pmlI A wild- type phenotype was restored following complementation with pmlI or addition of cell- free culture supernatant....
Homo sapiens
Gene: ... expression is inhibited by expression of PML- RARalpha in the absence of ligand and de novo superinduced... protein regulated by retinoic acid( RA) and promyelocytic leukemia( PML )- RA receptor alpha in acute... / Synonyms: PML-RAR; PML-RARA-regulated adapter molecule 1
MeSH term: ... - 1- 1 by PML was insignificant in the transient transfection experiment but significant in the PML...
Homo sapiens
Gene: ... , designated GLP( for Golgin linked to PML ), is strongly expressed as a 6- kb transcript in normal human...( CHRNA7) in 15q13. 3 and several Golgin- linked- to- PML, or LCR15, duplications. Analytical, diagnostic... numerous homologous bands outside the PML locus.... / Synonyms: Golgin linked to PML
Chemical compound: ... promoter. All- trans- retinoic acid induced reorganization of the PML nuclear body( NB) and reappearance... with a hemorrhagic disorder of unknown cause that responds to treatment with all- trans- retinoic acid. Tretinoin..., but diminished as the study progressed. Treatment with all- trans- retinoic acid reversed these changes providing...
MeSH term: ... feline and avian retroviral transforming genes, all of which encode functionally related proteins... be induced into remission with high dose RA therapy, we propose that the nonliganded PML- RAR protein... chain reaction( RT- PCR) analysis of messenger RNA encoded by the PML/ RAR- alpha oncogene were used...


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