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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GOLGA6A  -  golgin A6 family, member A

Homo sapiens

Synonyms: GLP, GOLGA6, Golgin linked to PML, Golgin subfamily A member 6A, Golgin-like protein
 
 
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High impact information on GOLGA6

  • Enhanced lymphocytes activation was seen after exposure to GLP and p62-75, whereas the simultaneous incubation with 10mer inhibits the lymphocytes response [1].
  • The gene, designated GLP (for Golgin linked to PML), is strongly expressed as a 6-kb transcript in normal human testis [2].
  • In situ hybridization of normal human testis demonstrated that the expression of GLP was restricted to late meiotic germ cells [2].
  • GLP is 50% homologous to other Golgin-related proteins including the vesicle docking protein GM130 [2].
  • This study, which was performed under GLP-like conditions, clearly indicates that FA does not induce MN in buccal mucosa cells after peak exposures up to 1ppm and a cumulative exposure of 13.5ppmh over 2 weeks [3].
 

Biological context of GOLGA6

  • Best Practices for Reporting Pathology Interpretations within GLP Toxicology Studies [4].
 

Associations of GOLGA6 with chemical compounds

  • Detailed analysis of the underlying sequence indicated that this region comprises multiple segmental duplications, including a previously characterized duplication of the alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) in 15q13.3 and several Golgin-linked-to-PML, or LCR15, duplications [5].
 

Analytical, diagnostic and therapeutic context of GOLGA6

  • Southern blot hybridization of genomic DNA with a GLP probe demonstrated numerous homologous bands outside the PML locus [2].

References

  1. A decapeptide from durum wheat prevents celiac peripheral blood lymphocytes from activation by gliadin peptides. Silano, M., DI Benedetto, R., Trecca, A., Arrabito, G., Leonardi, F., DE Vincenzi, M. Pediatr. Res. (2007) [Pubmed]
  2. Cloning and characterization of a Golgin-related gene from the large-scale polymorphism linked to the PML gene. Gilles, F., Goy, A., Remache, Y., Manova, K., Zelenetz, A.D. Genomics (2000) [Pubmed]
  3. Assessment of local genotoxic effects of formaldehyde in humans measured by the micronucleus test with exfoliated buccal mucosa cells. Speit, G., Schmid, O., Fröhler-Keller, M., Lang, I., Triebig, G. Mutat. Res. (2007) [Pubmed]
  4. Best Practices for Reporting Pathology Interpretations within GLP Toxicology Studies. Morton, D., Kemp, R.K., Francke-Carroll, S., Jensen, K., McCartney, J., Monticello, T.M., Perry, R., Pulido, O., Roome, N., Schafer, K., Sellers, R., Snyder, P.W. Toxicologic pathology (2006) [Pubmed]
  5. Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster. Locke, D.P., Archidiacono, N., Misceo, D., Cardone, M.F., Deschamps, S., Roe, B., Rocchi, M., Eichler, E.E. Genome Biol. (2003) [Pubmed]
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