Disease relevance of PRAM1

• The promyelocytic leukemia RARalpha target gene encoding an adaptor molecule-1 (PRAM-1) is involved in a signaling pathway induced by retinoic acid in acute promyelocytic leukemia (APL) cells [1].
• Based on the impression that very few SID victims have a dummy (comforter, pacifier) in their mouth at the time of death, and that a high proportion of SID babies were found dead in a carry-cot (portable crib, pram), a case-control study was performed [2].
• We conducted a 19-year follow-up study of 223 infants with myelomeningocele born by cephalic presentation, 68 born by pre-rupture of amniotic membranes cesarean section (PRAM C/S) and 155 born vaginally to determine outcome [3].
• Although tethered cord syndrome was more common in the PRAM C/S group (p = 0.02), there was no difference in the muscle strength loss between the PRAM C/S and the vaginally delivered groups [3].

Psychiatry related information on PRAM1

• It is recommended that pram-walking programmes for mothers with postnatal depression be implemented as pilot research into existing available services [4].
• The results suggest that the friendships formed in the pram walking group boosted mothers' satisfaction with social contact and possibly their mental health [5].
• CONCLUSIONS: Providing organised, community-based pram walking was not sufficient to increase overall physical activity levels among this group of postpartum women [5].

High impact information on PRAM1

• In contrast, mature PRAM-1-null neutrophils exhibit significant defects in adhesion-dependent reactive oxygen intermediate production and degranulation [6].
• Together, these findings demonstrate the uncoupling of key integrin-dependent responses in the absence of PRAM-1 and show this adaptor to be critical for select integrin functions in neutrophils [6].
• PRAM-1 potentiates arsenic trioxide-induced JNK activation [1].
• The cleavage of HIP-55 correlated with the induction of PRAM-1 mRNA and protein expression [1].
• Overexpression of PRAM-1 in the NB4 APL cell line increased arsenic trioxide-induced JNK activation through a caspase 3-like-dependent activity [1].

Biological context of PRAM1

• PRAM-1 is expressed and regulated during normal human myelopoiesis [7].
• The feasibility and effectiveness of pram walking groups for postpartum women in western Sydney [5].

Anatomical context of PRAM1

• Symptomatic hydromyelia was equally distributed but spinal cord hypoplasia was more common in the PRAM C/S group (p = 0.03) [3].

Associations of PRAM1 with chemical compounds

• PRAM-1 is required for optimal integrin-dependent neutrophil function [6].
• In U937 myeloid precursor cells, PRAM-1 expression is inhibited by expression of PML-RARalpha in the absence of ligand and de novo superinduced by retinoic acid [7].
• Two-dimensional thin-layer chromatography on cellulose plates has been used for separating and quantifying the three adenosine derivatives: AMP, phosphoribosyl AMP (PRAMP), and (PR)2AMP obtained by venom phosphodiesterase digestion of poly(ADP-ribose) [8].

Regulatory relationships of PRAM1

• PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells [7].

Analytical, diagnostic and therapeutic context of PRAM1

• In one case, death occurred in a baby car seat, another in a pram/stroller, and in another a curtain cord was responsible [9].
• The control group (n = 60) were also invited to participate in a pram walking group starting six months later [5].

References